^
    over3years
    Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up. (PubMed, Front Vet Sci)
    Our results suggest that local AdCD40L therapy is safe and could have beneficial effects in dogs, supporting further treatment development. Clinical translation to human patients is ongoing.
    Journal
    |
    CD40LG (CD40 ligand)
    |
    AdCD40L
    almost4years
    Intratumoral immunostimulatory AdCD40L gene therapy in patients with advanced solid tumors. (PubMed, Cancer Gene Ther)
    In conclusion, gene therapy by repeated intratumoral AdCD40L injections alone, or in combination with cyclophosphamide, is feasible and safe in patients with solid cancers. The potential of intratumoral CD40L gene transfer as treatment of cancer was illustrated by the clinical improvement in two out of seven patients.
    Clinical • Journal
    |
    CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD40LG (CD40 ligand)
    |
    AdCD40L • cyclophosphamide intravenous