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BIOMARKER:
ADAMTS1 expression
i
Other names: ADAMTS1, ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1, METH1, KIAA1346, C3-C5, A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 1, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1, Metalloprotease And Thrombospondin-1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, METH-1, Human Metalloproteinase With Thrombospondin Type 1 Motifs
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Furthermore, the higher ADAMTS9 expression was linked to prolonged survival, while the overexpression of ADAMTS12 was correlated with a shorter survival. These findings suggest that circRNA molecules may serve as potential diagnostic or prognostic biomarkers for NSCLC, highlighting the importance of considering molecular patterns in distinct cancer subtypes.
2 months ago
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CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • ADAMTS6 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 6) • ADAMTS12 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12)
Most importantly, API treatment significantly prolonged survival rates of xenograft mice with OSCC. In summary, ADAMTS1 may be a useful biomarker for predicting OSCC progression, and API potentially retarded OSCC progression by targeting the ADAMTS1-L1CAM-EGFR signaling pathway.
3 months ago
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ADAMTS1 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1) • L1CAM (L1 cell adhesion molecule)
Metformin can repress the proliferation and glycolysis of GC cells via ADAMTS12. The results suggest the potential of ADAMTS12 being a target for the metformin therapy of GC.
4 months ago
Journal
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CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • ADAMTS12 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12)
These phenotypic changes, together with the down-regulation of PAI-1, were offset by TGF-β treatment. The present study thus identifies ADAMTS12 as a modulator of HSC differentiation, and a new player in chronic liver disease.
These findings suggest that ADAMTS12 can modulate signaling via the MAPK/VEGF axis in GC cells to enhance tumor cell resistance to oxaliplatin treatment under hypoxic and normoxic conditions. Elevated ADAMTS12 levels can additionally predict vascular abnormalities, worse survival outcomes, and chemoresistance in patients with GC.
7 months ago
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VEGFA (Vascular endothelial growth factor A) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • ADAMTS12 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12)
Co-Immunoprecipitation combined with protein mass spectrometry showed that TGF-β signaling pathway-related proteins interacting with ADAMTS12 were screened from HeLa cells with ADAMTS12 overexpression. Therefore, we concluded that ADAMTS12 may affect the mTOR signaling pathway through the interacting with TGF-β1, and then affect the biological function of cervical cancer cells.
8 months ago
Journal
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EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) • TGFB1 (Transforming Growth Factor Beta 1)
Pearson correlation analysis of sample data showed that there was a negative correlation between the expression of ADAMTS18 and PD-L1 in tumor tissues. In conclusion, the Chinese herbal compound SanHuang decoction can reverse axitinib resistance in ccRCC cells by regulating immune cell infiltration and affecting ADAMTS18 expression.
Such inhibitory effect may be ascribed to the involvement of AKT/mammalian target of rapamycin signaling. Hence, the present study of ADAMTS16 will provide new insight into the underlying biological mechanisms of ccRCC.
These proteins were up-regulated in lung tumour samples, and high PXDN and ADAMTS16 gene expression was associated with shorter survival of lung adenocarcinoma and squamous cell carcinoma patients, respectively. These data chart extensive remodelling of the lung extracellular niche and reveal tumour matrisome signatures in human NSCLC.
Further analysis revealed that ADAMTS16 expression was associated with necrosis and cholestasis, and BMP2 expression was associated with the Barcelona Clinic Liver Cancer stage and the vessels encapsulating tumor clusters. Overall, the findings of the present study provided insights into the possible mechanisms of TB in HCC and revealed potential anti-HCC therapeutic targets.
si-TGF-β or inhibition of TGF-β expression through the short peptide KTFR on ADAMTS1 protein could reverse the oncogenic effects of ADAMTS1 on lung cancer cells. Taken together, ADAMTS1 functioned as an oncogene in NSCLC cells by promoting TGF-β expression, indicating that ADAMTS1 has important regulatory roles in the progression of NSCLC.
1 year ago
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TGFB1 (Transforming Growth Factor Beta 1) • ADAMTS1 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1)