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    BIOMARKER:

    ACTA2 underexpression

    i
    Other names: ACTA2, Actin Alpha 2 Smooth Muscle, ACTSA, Cell Growth-Inhibiting Gene 46 Protein, Actin Alpha 2 Smooth Muscle Aorta, Actin Aortic Smooth Muscle, Alpha-Cardiac Actin, Alpha-Actin-2, ACTA2, ACTVS
    Entrez ID:
    59
    Related biomarkers:
    Expression
    Others
    2years
    ACTA2 expression predicts survival and is associated with response to immune checkpoint inhibitors in gastric cancer. (PubMed, Clin Cancer Res)
    ACTA2 expression is associated with survival and ICI response in gastric cancer patients. ACTA2 expression in cancer-associated fibroblasts, but not in other cellular compartments, appears to be associated with ICI response.
    Journal • Checkpoint inhibition • MSi-H Biomarker • IO biomarker
    |
    MSI (Microsatellite instability) • ACTA2 (Actin Alpha 2 Smooth Muscle)
    |
    MSI-H/dMMR • ACTA2 overexpression • ACTA2 underexpression