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GENE:

ACTA1 (Actin Alpha 1, Skeletal Muscle)

News alerts, weekly reports and conference planners

25d

Biomimetic core-shell breast cancer models using alginate, gelatin, and collagen I: simulating the tumor matrix for drug evaluation. (PubMed, Int J Biol Macromol)

Breast cancer cells proliferated in the core of all prototypes designed, forming spheroids and cell aggregates with a high resistance to doxorubicin. The addition of Collagen I to the developed model enabled the upregulation of malignancy markers (Col1A1, Ki67, FOXC2, SNAI1, NFKB1, WWTR1), invasion markers (WASL, ACTA1, MYO1E, TPM4, PODXL, ITGA2, ITGA5, MENA, EGFR, CDC42), and drug resistance markers (ABCG2, CYP1A1, BAX, HSP90AA1) occurring in vivo. The developed 3D in vitro model can clarify the contribution of the extracellular matrix to the tumor outcome and drug efficacy by replicating some key characteristics of breast tumors, establishing a novel tool for chemotherapeutic agents and drug screening.

25 days ago

Preclinical • Journal

EGFR (Epidermal growth factor receptor) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • BAX (BCL2-associated X protein) • COL1A1 (Collagen Type I Alpha 1 Chain) • WWTR1 (WW Domain Containing Transcription Regulator 1) • CDC42 (Cell Division Cycle 42) • PODXL (Podocalyxin) • SNAI1 (Snail Family Transcriptional Repressor 1) • TPM4 (Tropomyosin 4) • ACTA1 (Actin Alpha 1, Skeletal Muscle) • CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • ITGA2 (Integrin Subunit Alpha 2) • ITGA5 (Integrin Subunit Alpha 5) • FOXC2 (Forkhead Box C2)

doxorubicin hydrochloride

8ms

High GLP1R gene copy numbers associated with microsatellite instability for multiple cancers and with better survival probabilities for glioblastoma. (PubMed, Cell Cycle)

Results also indicated that high microsatellite instability directly correlated with high CNs for most of the above indicated genes. These approaches to assessing tumor metabolism-related genes may lead to more accurate measures of patient risk and potential additional treatment options.

8 months ago

Journal • Microsatellite instability

MSI (Microsatellite instability) • ACTA1 (Actin Alpha 1, Skeletal Muscle) • GCG (Glucagon)

MSI-H/dMMR

10ms

An Evaluation of Prognostic Factors in Cutaneous Squamous Cell Carcinoma: A Single-Center Study of 237 Japanese Cases. (PubMed, J Clin Med)

RNA sequencing revealed the significant amplification of ACTA1, which was confirmed by Western blotting and immunohistochemical staining. These results suggest that HS is a prognostic factor in cSCC and that LL-37 stimulation contributes to tumor progression, partly by enhancing multiple tumor growth factors.

10 months ago

Journal

ACTA1 (Actin Alpha 1, Skeletal Muscle)

11ms

Comparative transcriptomic analysis of primary endometrial cancer and bone metastatic cancer: metastasis-associated genes and abnormal cell cycle regulation. (PubMed, Discov Oncol)

Our research identified genes and key signaling pathways associated with bone metastasis. These findings provide a theoretical basis for the treatment of bone metastasis in EC.

11 months ago

Journal

ICAM1 (Intercellular adhesion molecule 1) • SOX2 • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • CDK1 (Cyclin-dependent kinase 1) • ACTA1 (Actin Alpha 1, Skeletal Muscle) • E2F1 (E2F transcription factor 1) • MCM2 (Minichromosome maintenance complex component 2)

11ms

Gastric adenocarcinoma with enteroblastic differentiation. (PubMed, Pathobiology)

GAED is a rare subtype of gastric adenocarcinomas, representing 0.3-5.4% of all cases and has an unclarified etiology. Our WES results identified new pathogenic and likely pathogenic mutations. From a differential diagnostic point of view, hepatoid adenocarcinoma, and the possibility of metastatic origin has to be excluded.

11 months ago

Journal

TP53 (Tumor protein P53) • GPC3 (Glypican 3) • SALL4 (Spalt Like Transcription Factor 4) • ACTA1 (Actin Alpha 1, Skeletal Muscle) • HNF1A (HNF1 Homeobox A)

1year

Integrating clinical and genomic landscape analysis of perineural invasion identify ACTA1 as an oncogene for oral squamous cell carcinoma. (PubMed, Front Cell Dev Biol)

Among them, Actin α1 (ACTA1) was significantly upregulated in PNI+ advanced OSCC with worse clinical outcome whose had relatively low ratio of CD3+CD8+ circulating cytotoxic T cells. PNI+ OSCC patients with upregulated of Actin α1 could benefit from cytotoxic T cell-mediated immunotherapy.

1 year ago

Journal • IO biomarker

CD8 (cluster of differentiation 8) • ACTA1 (Actin Alpha 1, Skeletal Muscle)

over1year

Immune cell infiltration and drug response in glioblastoma multiforme: insights from oxidative stress-related genes. (PubMed, Cancer Cell Int)

The risk model, built upon 9 ORGs and the identification of GBM subtypes, suggests that ORGs have a broad application prospect in the clinical immunotherapy and targeted drug treatment of GBM. HADHA significantly influences the development of gliomas, both in vivo and in vitro.

over 1 year ago

Journal • IO biomarker • Immune cell

CCND1 (Cyclin D1) • SPP1 (Secreted Phosphoprotein 1) • EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1) • TXNIP (Thioredoxin Interacting Protein) • ACTA1 (Actin Alpha 1, Skeletal Muscle) • BMP2 (Bone Morphogenetic Protein 2)

almost2years

Systems biology approach to identify biomarkers and therapeutic targets for colorectal cancer. (PubMed, Biochem Biophys Rep)

Our results identified several genes with high centrality in PPI network that contribute to progression of CRC. The fact that several of the identified genes have already been reported to be relevant to diagnosis and treatment of CRC, other highlighted genes with limited literature information may hold potential to be explored in the context of CRC biomarker and drug target discovery.

almost 2 years ago

Journal

CCNA2 (Cyclin A2) • ACAN (Aggrecan) • ACTA1 (Actin Alpha 1, Skeletal Muscle) • TRPC1 (Transient Receptor Potential Cation Channel Subfamily C Member 1)

CD44 expression

2years

Coding RNA expression profile and transcription factor analysis of H.pylori-associated chronic atrophic gastritis. (PubMed, Adv Med Sci)

The expression of APOA1, CYP3A4, FOXP3, CCR7, and CCL19 are the potential indicators for CAG to GC development, being the biomarkers to predict progression of CAG and poor prognosis of GC.

2 years ago

Journal

CCL19 (C-C Motif Chemokine Ligand 19) • CCR7 (Chemokine (C-C motif) receptor 7) • FOXP3 (Forkhead Box P3) • APOA1 (Apolipoprotein A-I) • CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4) • ACTA1 (Actin Alpha 1, Skeletal Muscle)

FOXP3 expression

2years

Elucidating Cuproptosis-Associated Genes in the Progression from Nash to HCC Using Bulk and Single-Cell RNA Sequencing Analyses and Experimental Validation. (PubMed, Medicina (Kaunas))

The present study identified key CRGs, revealing their potential impact on NASH and HCC. Meanwhile, targeting FDX1 may prevent the progression of NASH to HCC.

2 years ago

Journal

CXCL10 (Chemokine (C-X-C motif) ligand 10) • DLAT (Dihydrolipoamide S-Acetyltransferase) • ACTA1 (Actin Alpha 1, Skeletal Muscle) • FDX1 (Ferredoxin 1) • LIPT1 (Lipoyltransferase 1) • SLC31A1 (Solute Carrier Family 31 Member 1)

over2years

Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the Barrett's esophagus in rats. (PubMed, Genomics)

Our study is the first to perform comprehensive and transcriptome-wide maps to identify the potential roles played by m6A methylation in BE, which widely involved in oxidative stress. This foresees a guiding role in revealing the molecular mechanism of m6A-mediated genes that govern the pathogenesis and progression of BE and EAC.

over 2 years ago

Preclinical • Journal

CDC20 (Cell Division Cycle 20) • ACTA1 (Actin Alpha 1, Skeletal Muscle) • KIF20A (Kinesin Family Member 20A) • TPM2 (Tropomyosin 2)