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    BIOMARKER:

    ACSM3 overexpression

    i
    Other names: ACSM3, Acyl-CoA Synthetase Medium Chain Family Member 3, Acyl-Coenzyme A Synthetase ACSM3, Mitochondrial, SA (Rat Hypertension-Associated) Homolog, Middle-Chain Acyl-CoA Synthetase 3, Butyryl-Coenzyme A Synthetase 3, Butyrate--CoA Ligase 3, Propionate--CoA Ligase, Protein SA Homolog, SAH, SA, Acyl-CoA Synthetase Medium-Chain Family Member, SA Hypertension-Associated Homolog (Rat), SA Hypertension-Associated Homolog
    Entrez ID:
    6296
    8ms
    Acyl-CoA Medium-Chain Synthetase-3 (ACSM3) Is Regulated by Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) and Inhibits Proliferation, Motility and Stem Cell Properties of Breast Invasive Carcinoma. (PubMed, Ann Clin Lab Sci)
    We found that ACSM3 was regulated by IGF2BP3 and attenuated BRCA proliferation, invasion and stem cell properties. The role of ACSM3 in BRCA was first revealed, which provides a novel target for treatment.
    Journal • BRCA Biomarker
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    BRCA (Breast cancer early onset) • ACSM3 (Acyl-CoA Synthetase Medium Chain Family Member 3) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3)
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    ACSM3 overexpression
    1year
    ACSM3 suppresses proliferation and induces apoptosis and cell cycle arrest in acute myeloid leukemia cells via the regulation of IGF2BP2. (PubMed, Exp Ther Med)
    mRNA stabilization of ACSM3 following actinomycin D treatment was evaluated using reverse transcription-quantitative PCR analysis...In addition, IGF2BP2 overexpression counteracted the effects of ACSM3 overexpression noted on proliferation, induction of apoptosis and cell cycle arrest of HL-60 cells. In conclusion, ACSM3 repressed the cell proliferative activity and facilitated induction of apoptosis and cell cycle arrest in AML cells by modulating the expression of IGF2BP2.
    Journal
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    IGF2 (Insulin-like growth factor 2) • ACSM3 (Acyl-CoA Synthetase Medium Chain Family Member 3) • IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2)
    |
    ACSM3 overexpression
    |
    dactinomycin
    2years
    ACSM3 suppresses the pathogenesis of high-grade serous ovarian carcinoma via promoting AMPK activity. (PubMed, Cell Oncol (Dordr))
    Our data indicate that the ACSM3-AMPK axis is involved in the pathogenesis of HGSOC and, as such, may act as a therapeutic target for this cancer.
    Journal
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    ACSM3 (Acyl-CoA Synthetase Medium Chain Family Member 3) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
    |
    ACSM3 overexpression
    3years
    The Overexpression of Acyl-CoA Medium-Chain Synthetase-3 (ACSM3) Suppresses the Ovarian Cancer Progression via the Inhibition of Integrin β1/AKT Signaling Pathway. (PubMed, Front Oncol)
    And ACSM3 interference obtained the contrary effects in vivo. In summary, ACSM3 acts as a tumor suppressor gene and may be a potential therapeutic target of ovarian cancer.
    Journal
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    ACSM3 (Acyl-CoA Synthetase Medium Chain Family Member 3)
    |
    ACSM3 overexpression