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    BIOMARKER:

    ACLY underexpression

    i
    Other names: ACLY, ATP Citrate Lyase, ACL, ATPCL, CLATP, ATP-Citrate (Pro-S-)-Lyase, Citrate Cleavage Enzyme, ATP-Citrate Synthase, ATP Citrate Synthase
    Entrez ID:
    47
    5ms
    Activation of HIF-1α/ACLY signaling axis promotes progression of clear cell renal cell carcinoma with VHL inactivation mutation (PubMed, Zhonghua Bing Li Xue Za Zhi)
    VHL mutation-mediated HIF-1α overexpression in ccRCC promotes lipid synthesis and tumor progression by activating ACLY. Targeting the HIF-1α/ACLY signaling axis may provide a theoretical basis for the clinical diagnosis and treatment of ccRCC.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • VHL (von Hippel-Lindau tumor suppressor) • ACLY (ATP Citrate Lyase)
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    VHL mutation • HIF1A overexpression • HIF1A expression • ACLY underexpression