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    GENE:

    ACKR4 (Atypical Chemokine Receptor 4)

    i
    Other names: ACKR4, Atypical Chemokine Receptor 4, CCR11, CCBP2, VSHK1, CCX-CKR, CCRL1, PPR1, Chemokine (C-C Motif) Receptor-Like 1, C-C Chemokine Receptor Type 11, CC Chemokine Receptor-Like 1, C-C CKR-11, CC-CKR-11, CCX CKR, CCR-11, Orphan Seven-Transmembrane Receptor, Chemokine Related, Chemokine, Cc Motif, Receptor-Like Protein 1, Chemocentryx Chemokine Receptor, CKR-11, CCR10
    Associations

    News

    Trials
    5ms
    Nano-Luciferase complementation assay of human herpesvirus 8 chemo/cytokine-receptor interactions. (PubMed, Sci Rep)
    Likewise, we used NanoBiT to monitor vIL-6 binding to its receptor gp130 and downstream signaling via STAT3. In sum, we demonstrate the utility of NanoBiT for assessing viral chemo/cytokine-receptor interactions and signaling and its potential in screening for antibodies to treat HHV-8 infection and related diseases.
    Journal
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    IL6 (Interleukin 6) • STAT3 (Signal Transducer And Activator Of Transcription 3) • ACKR4 (Atypical Chemokine Receptor 4)
    1year
    International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5. (PubMed, Pharmacol Rev)
    Taken together, compelling cumulative evidence indicates that GPR182 does not trigger G protein-mediated signaling but acts as a scavenger for chemokines in vitro and in vivo, strongly supporting its inclusion as ACKR5 in the systematic nomenclature of chemokine receptors. SIGNIFICANCE STATEMENT: The summarized presented findings strongly support the designation of GPR182 as ACKR5 and its formal inclusion in the family of ACKRs.
    Review • Journal
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    ACKR3 (Atypical Chemokine Receptor 3) • ACKR4 (Atypical Chemokine Receptor 4)
    over1year
    Unraveling the Multifaceted Roles of Atypical Chemokine Receptors in Breast Cancer. (PubMed, J Interferon Cytokine Res)
    Additionally, we will explore the potential of ACKRs as diagnostic and prognostic markers and assess their viability as therapeutic targets. By synthesizing recent research findings and highlighting future research directions, this review seeks to provide a comprehensive understanding of the significance of ACKRs in BC and underscore the need for continued investigation into their therapeutic potential.
    Review • Journal
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    ACKR3 (Atypical Chemokine Receptor 3) • ACKR1 (Atypical Chemokine Receptor 1) • ACKR4 (Atypical Chemokine Receptor 4)
    over1year
    Clinical Aspects and Significance of β-Chemokines, γ-Chemokines, and δ-Chemokines in Molecular Cancer Processes in Acute Myeloid Leukemia (AML) and Myelodysplastic Neoplasms (MDS). (PubMed, Cancers (Basel))
    The focus is on the effects of these chemokines on AML cells, particularly their influence on proliferation and resistance to anti-leukemic drugs. Intercellular interactions with non-AML cells, such as mesenchymal stem cells (MSC), macrophages, and regulatory T cells (Treg), are also characterized. The clinical aspects of chemokines are thoroughly explained, including their effect on overall survival and the relationship between their blood levels and AML characteristics.
    Review • Journal
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    CCL2 (Chemokine (C-C motif) ligand 2) • CCL23 (Chemokine (C-C motif) ligand 23) • CCL3 (C-C Motif Chemokine Ligand 3) • CX3CL1 (C-X3-C Motif Chemokine Ligand 1) • ACKR1 (Atypical Chemokine Receptor 1) • ACKR4 (Atypical Chemokine Receptor 4)
    over1year
    International Union of Basic and Clinical Pharmacology. CXVIII. Update on the Nomenclature for Atypical Chemokine Receptors including ACKR5. (PubMed, Pharmacol Rev)
    Taken together, compelling cumulative evidence indicates that GPR182 does not trigger G protein-mediated signaling but acts as a scavenger for chemokines in vitro and in vivo strongly supporting its inclusion as ACKR5 in the systematic nomenclature of chemokine receptors. Significance Statement The summarized presented findings strongly support the designation of GPR182 as ACKR5 and its formal inclusion in the family of atypical chemokine receptors.
    Journal
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    ACKR3 (Atypical Chemokine Receptor 3) • ACKR4 (Atypical Chemokine Receptor 4)
    over1year
    Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas. (PubMed, Elife)
    Furthermore, the knockout of ACKR4 increased the chemokine-guided migration of Burkitt lymphoma cells. These data demonstrate the functional relevance of alternatively spliced p53 isoforms and reveal sex disparities in Myc-driven lymphomagenesis.
    Preclinical • Journal
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    ACKR4 (Atypical Chemokine Receptor 4)
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    TP53 mutation • TP53 expression
    over1year
    Development of specific anti-mouse atypical chemokine receptor 4 monoclonal antibodies. (PubMed, Biochem Biophys Rep)
    Furthermore, A4Mab-1 and A4Mab-2 could detect mACKR4 by western blotting. These results indicated that A4Mab-1, A4Mab-2, and A4Mab-3 help to detect mACKR4 by flow cytometry and western blotting and obtain the proof of concept in preclinical models.
    Preclinical • Journal
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    ACKR4 (Atypical Chemokine Receptor 4)
    over1year
    Single-cell analysis reveals the disparities in immune profiles between younger and elder patients. (PubMed, Eur Geriatr Med)
    This study reveals the distinct immune profiles between younger and elder NSCLC patients, and the elder patients were likely to exhibit a more immunosuppressive TME and attenuated tumor-killing capability compared with younger patients.
    Journal
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • SPP1 (Secreted Phosphoprotein 1) • CSF1 (Colony stimulating factor 1) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • CD86 (CD86 Molecule) • NECTIN2 (Nectin Cell Adhesion Molecule 2) • SIRPA (Signal Regulatory Protein Alpha) • ACKR4 (Atypical Chemokine Receptor 4)
    almost2years
    Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A comprehensive exploration across physiological and pathological landscapes in contemporary research. (PubMed, Cell Biochem Funct)
    The study of ACKR4 is still ongoing, and further research is needed to fully understand its role in different physiological and pathological contexts. Nonetheless, ACKR4 represents a promising target for the development of novel therapeutic strategies for various diseases.
    Review • Journal
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    ACKR4 (Atypical Chemokine Receptor 4)
    almost2years
    Differential expression of chemokine genes by race and Breast Cancer Consensus Subtypes in hormone receptor positive breast cancer (AACR 2024)
    Our findings show that AAW with HR+ breast cancer have tumors with more inherently aggressive molecular subtypes associated with poor prognosis compared to EAW. These results also further support the premise that HR+/HER2- tumors are highly heterogeneous and strongly suggest that chemokine gene expression is associated with breast cancer subtype.
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCR1 (Chemokine (C-X-C motif) receptor 1) • CXCR2 (Chemokine (C-X-C motif) receptor 2) • CXCR6 (C-X-C Motif Chemokine Receptor 6) • CCR3 (C-C Motif Chemokine Receptor 3) • CCR6 (C-C Motif Chemokine Receptor 6) • CX3CR1 (C-X3-C Motif Chemokine Receptor 1) • ACKR1 (Atypical Chemokine Receptor 1) • ACKR4 (Atypical Chemokine Receptor 4)
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    HR positive • HER-2 negative • ER negative
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    Prosigna™ Breast Cancer Prognostic Gene Signature Assay
    2years
    Atypical chemokine receptors in cancer. (PubMed, Cytokine)
    This is particularly true for ACKR1, ACKR2 and ACKR4. A better understanding of how ACKR expression and functions impact cancer should pave the way for their future targeting by new and effective therapies.
    Journal
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    ACKR3 (Atypical Chemokine Receptor 3) • ACKR1 (Atypical Chemokine Receptor 1) • ACKR4 (Atypical Chemokine Receptor 4)