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    DRUG:

    aCD21 CAR

    i
    Other names: aCD21 CAR, anti-CD21 chimeric antigen receptor T cells
    Associations

    News

    Trials
    Company:
    Autolus, University College London
    Drug class:
    CD21-targeted CAR-T immunotherapy
    Associations

    News

    Trials
    over4years
    Anti-CD21 Chimeric Antigen Receptor (CAR)-T Cells for T Cell Acute Lymphoblastic Leukaemia (T-ALL) (ASH 2021)
    Its expression is largely restricted to the malignant T cell compartment, overcoming issues with fratricide and on-target off-tumour effects seen in many T-ALL CAR-T strategies to date. Despite the complexity of the target, we have successfully generated an aCD21 CAR that is functional both in vitro and in vivo .
    IO biomarker
    |
    CD19 (CD19 Molecule) • IFNG (Interferon, gamma) • CD5 (CD5 Molecule) • CD7 (CD7 Molecule)
    |
    aCD21 CAR