^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    ACAT1 overexpression

    i
    Other names: ACAT1, Acetyl-CoA Acetyltransferase 1, Acetyl-CoA Acetyltransferase, Mitochondrial, Acetyl-Coenzyme A Acetyltransferase 1, Acetoacetyl Coenzyme A Thiolase, Acetoacetyl-CoA Thiolase, ACAT, THIL, Mitochondrial Acetoacetyl-CoA Thiolase, Testicular Tissue Protein Li 198
    Entrez ID:
    38
    over1year
    From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer. (PubMed, Front Immunol)
    In addition, ACAT1 overexpression inhibited cell migration and invasion, improved the response to 5-Fluorouracil (5-FU) and etoposide. Correlation analysis indicated ACAT1 mRNA expression was correlated with immune infiltrates. Collectively, our data show that ACAT1 induces pronounced inhibitory effects on gastric cancer initiation and development, which may impact future strategies to treat this aggressive cancer.
    Journal
    |
    CDH1 (Cadherin 1) • CD44 (CD44 Molecule) • CD24 (CD24 Molecule) • POU5F1 (POU Class 5 Homeobox 1) • VIM (Vimentin) • ACAT1 (Acetyl-CoA Acetyltransferase 1)
    |
    CD44 expression • CDH1 expression • VIM expression • ACAT1 overexpression • CD24 expression • POU5F1 expression
    |
    5-fluorouracil • etoposide IV
    almost3years
    Avasimibe abolishes the breast cancer preventative efficacy of statin in a spontaneous mouse model of breast cancer (AACR 2023)
    We postulate that avasimibe enhanced metabolism of fluvastatin in mouse system and thus completely abolishing the chemopreventive effects of statin. Genomically derived rationale drug combinations may result in unanticipated interactions and/or ancillary effects that limit efficacy in vivo/ in patients.
    Preclinical
    |
    ACAT1 (Acetyl-CoA Acetyltransferase 1) • HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1)
    |
    ACAT1 overexpression