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GENE:

ACAA2 (Acetyl-CoA Acyltransferase 2)

i
Other names: ACAA2, Acetyl-CoA Acyltransferase 2, DSAEC, Mitochondrial 3-Oxoacyl-Coenzyme A Thiolase, 3-Ketoacyl-CoA Thiolase, Mitochondrial, Mitochondrial 3-Oxoacyl-CoA Thiolase, Acetyl-Coenzyme A Acyltransferase 2, Acyl-CoA Hydrolase, Mitochondrial, Acetyl-CoA Acetyltransferase, T1, Acetyl-CoA Acyltransferase, Beta Ketothiolase, Beta-Ketothiolase
Associations
Trials
3ms
The metabolic crossroads: glycolysis in cancer and neurodegeneration. (PubMed, BMC Neurol)
Our findings identify glycolysis as a shared but oppositely regulated pathway linking cancer and neurodegeneration. ACAA2 may serve as a molecular mediator of this metabolic divergence, offering new insights into disease crosstalk and potential therapeutic targets.
Journal
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ACAA2 (Acetyl-CoA Acyltransferase 2)
almost2years
The oncogenic role and regulatory mechanism of ACAA2 in human ovarian cancer. (PubMed, Mol Carcinog)
ACAA2 regulated the malignant progression of ovarian cancer through the WNT/β-Catenin signaling pathway probably. ACAA2 is an oncogene in ovarian cancer and has the potential to be a target for ovarian cancer therapy.
Journal
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ACAA2 (Acetyl-CoA Acyltransferase 2)
2years
ACAA2 is a novel molecular indicator for cancers with neuroendocrine phenotype. (PubMed, Br J Cancer)
ACAA2 expression is elevated in aggressive SCNCs such as NEPC and SCLC, suggesting it is a potential molecular indicator for SCNCs.
Journal
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ACAA2 (Acetyl-CoA Acyltransferase 2)
over2years
Downregulated Acetyl-CoA Acyltransferase 2 Promoted the Progression of Hepatocellular Carcinoma and Participated in the Formation of Immunosuppressive Microenvironment. (PubMed, J Hepatocell Carcinoma)
In a conclusion, downregulated ACAA2 promoted the progression of hepatocellular carcinoma and might be participated in the formation of immunosuppressive microenvironment. ACAA2 could be served as a favorable indicator for the prognosis of HCC and an ideal biomarker for immunotherapy.
Journal • IO biomarker
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HLA-E (Major Histocompatibility Complex, Class I, E) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • ACAA2 (Acetyl-CoA Acyltransferase 2)
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FOXP3 expression