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    DRUG:

    albumin-bound paclitaxel

    i
    Other names: ABI007, ABI-007, SNA-001, HC007
    Company:
    Generic mfg.
    Drug class:
    Tubulin inhibitor
    Related drugs:
    1d
    Paclitaxel Protein Bound Plus Cisplatin Plus Gemcitabine and Paricalcitol for Pancreatic Adenocarcinoma (NABPLAGEMD) (clinicaltrials.gov)
    P2, N=34, Completed, HonorHealth Research Institute | N=11 --> 34
    Enrollment change
    |
    CA 19-9 (Cancer antigen 19-9)
    |
    cisplatin • gemcitabine • albumin-bound paclitaxel
    1d
    SPECTACLE: Study of Paclitaxel Polymeric Micelles Combined With HP and Adebelimab Versus Taxane Combined With HP as First-Line Treatment for Advanced HER2-Positive Breast Cancer (clinicaltrials.gov)
    P2, N=140, Not yet recruiting, Fudan University
    New P2 trial
    |
    HER-2 positive
    |
    Herceptin (trastuzumab) • docetaxel • Perjeta (pertuzumab) • albumin-bound paclitaxel • AiRuiLi (adebrelimab)
    1d
    MAGELLAN: A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC (clinicaltrials.gov)
    P1, N=175, Active, not recruiting, AstraZeneca | Trial completion date: Mar 2026 --> Jul 2026
    Trial completion date
    |
    EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • ALK (Anaplastic lymphoma kinase)
    |
    EGFR mutation • ALK fusion
    |
    cisplatin • carboplatin • Imfinzi (durvalumab) • gemcitabine • albumin-bound paclitaxel • pemetrexed • oleclumab (MEDI9447) • rilvegostomig (AZD2936) • volrustomig (MEDI5752) • danvatirsen (AZD9150)
    2d
    A Randomized Phase II Study of Priming Treatment With the Hedgehog Inhibitor NLM-001 Prior to Gemcitabine/Nab-Paclitaxel (GNab-P) plusBotensilimab and Balstilimab (Bot/Bal) Versus GNab-P in Patients With Previously Untreated Advanced Pancreatic Cancer (NUMANTIA-2) (clinicaltrials.gov)
    P2, N=40, Not yet recruiting, Nelum Corp
    New P2 trial
    |
    gemcitabine • albumin-bound paclitaxel • balstilimab (AGEN2034) • botensilimab (AGEN1181) • NLM-001
    3d
    CA-4948 Added to Standard Chemotherapy to Treat Metastatic or Unresectable Pancreatic Cancer (clinicaltrials.gov)
    P1, N=43, Suspended, National Cancer Institute (NCI) | Recruiting --> Suspended
    Trial suspension
    |
    gemcitabine • albumin-bound paclitaxel • emavusertib (CA-4948)
    4d
    Heparanase blockade sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy and unleashes antitumor immunity. (PubMed, Biomed Pharmacother)
    Importantly, triple therapy with PI-88, gemcitabine, and Abraxane significantly suppressed tumor growth and prolonged survival relative to all mono- and doublet regimens. Immune profiling revealed that this combination reduced PSC activation, contracted M2 macrophage and regulatory T cell populations, and expanded M1 macrophages, CD8⁺ T cells, and NK cells. In conclusion, these data underscore HPSE as a key driver of fibrosis and chemoresistance in PDAC and support HPSE inhibition as a promising strategy to enhance therapeutic efficacy.
    Journal
    |
    CD8 (cluster of differentiation 8)
    |
    gemcitabine • albumin-bound paclitaxel • muparfostat (PI-88)
    7d
    CTP-PANC-09: Alpha Radiation Emitters Device (DaRT) With Chemotherapy for the Treatment of Locally Advanced and Metastatic Pancreatic Cancer (clinicaltrials.gov)
    P=N/A, N=40, Recruiting, Alpha Tau Medical LTD. | N=30 --> 40
    Enrollment change
    |
    albumin-bound paclitaxel • irinotecan
    8d
    A retrospective study of PD-1 monoclonal antibody combined with nab-paclitaxel plus bevacizumab in the treatment of advanced malignant melanoma (PubMed, Zhonghua Zhong Liu Za Zhi)
    Patients received combination therapy with nab-paclitaxel, bevacizumab, and toripalimab (Q3W) at Nanjing Drum Tower Hospital. Furthermore, this triplet therapy combined with radiotherapy significantly improves PFS. Preliminary biomarker analysis suggests that patients with liver metastasis, MET or NF1 mutations may be less likely to benefit from this treatment regimen.
    Retrospective data • Journal • PD(L)-1 Biomarker • IO biomarker
    |
    MET (MET proto-oncogene, receptor tyrosine kinase) • NF1 (Neurofibromin 1)
    |
    MET mutation
    |
    Avastin (bevacizumab) • Loqtorzi (toripalimab-tpzi) • albumin-bound paclitaxel
    8d
    A Clinical Study on the Treatment of LACC With Cadonilimab Combined With Chemotherapy Followed by CCRT (clinicaltrials.gov)
    P3, N=378, Recruiting, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Not yet recruiting --> Recruiting
    Enrollment open
    |
    cisplatin • albumin-bound paclitaxel • Kaitanni (cadonilimab)
    8d
    Safety and Efficacy of Radiotherapy Combined With Immunochemotherapy in Pre-treated SCLC Patients With Liver Metastases (clinicaltrials.gov)
    P2, N=30, Not yet recruiting, Sichuan University | Initiation date: Dec 2025 --> Oct 2026
    Trial initiation date
    |
    albumin-bound paclitaxel • etoposide IV • irinotecan • Zepzelca (lurbinectedin)
    9d
    New and Emerging Therapies for the Treatment of Resectable, Borderline Resectable, or Locally Advanced Pancreatic Cancer, PIONEER-Panc Study (clinicaltrials.gov)
    P2, N=0, Withdrawn, M.D. Anderson Cancer Center | N=105 --> 0 | Trial completion date: Apr 2027 --> Apr 2026 | Active, not recruiting --> Withdrawn | Trial primary completion date: Apr 2027 --> Apr 2026
    Enrollment change • Trial completion date • Trial withdrawal • Trial primary completion date
    |
    cisplatin • gemcitabine • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    9d
    TEADCO: A 2-part Phase 1/2 Open-label Trial on ODM-212 (clinicaltrials.gov)
    P1/2, N=229, Recruiting, Orion Corporation, Orion Pharma
    New P1/2 trial
    |
    PD-L1 (Programmed death ligand 1) • KRAS (KRAS proto-oncogene GTPase)
    |
    KRAS mutation
    |
    Opdivo (nivolumab) • Yervoy (ipilimumab) • gemcitabine • Lumakras (sotorasib) • albumin-bound paclitaxel