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    GENE:

    ABCF2 (ATP Binding Cassette Subfamily F Member 2)

    i
    Other names: ABCF2, ATP Binding Cassette Subfamily F Member 2, EST133090, HUSSY-18, ABC28, ATP-Binding Cassette, Sub-Family F (GCN20), Member 2, ATP-Binding Cassette Sub-Family F Member 2, Iron-Inhibited ABC Transporter 2, M-ABC1, ABC-Type Transport Protein, HUSSY18
    Associations

    News

    Trials
    1year
    Phase 1 Dose Escalation of ArtemiCoffee (clinicaltrials.gov)
    P1, N=13, Completed, Frederick R. Ueland, M.D. | Active, not recruiting --> Completed
    Trial completion
    |
    CD99 (CD99 Molecule) • ABCF2 (ATP Binding Cassette Subfamily F Member 2)
    over1year
    The association of ABC proteins with multidrug resistance in cancer. (PubMed, Biochim Biophys Acta Mol Cell Res)
    We further discussed that the most commonly used drugs in standard regimens for mainly breast cancer, lung cancer, and acute lymphoblastic leukemia could be subject to MDR mediated by ABC transporters. Collectively, these insights will aid in conducting new studies aimed at a deeper understanding of the clinical MDR mediated by ABC proteins and in designing more effective pharmacological treatments to enhance the objective response rate in cancer patients.
    Review • Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • ABCC10 (ATP Binding Cassette Subfamily C Member 10) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • ABCF2 (ATP Binding Cassette Subfamily F Member 2) • ABCG1 (ATP Binding Cassette Subfamily G Member 1) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    over1year
    Identification of prognostic biomarkers for hepatocellular carcinoma with vascular invasion. (PubMed, Am J Transl Res)
    The study indicates that 7 genes may be potential prognostic biomarkers and treatment targets for HCC patients with VI.
    Journal
    |
    ABCF2 (ATP Binding Cassette Subfamily F Member 2) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
    over1year
    Phase 1 Dose Escalation of ArtemiCoffee (clinicaltrials.gov)
    P1, N=13, Active, not recruiting, Frederick R. Ueland, M.D. | Recruiting --> Active, not recruiting
    Enrollment closed • Metastases
    |
    CD99 (CD99 Molecule) • ABCF2 (ATP Binding Cassette Subfamily F Member 2)
    2years
    Phase 1 Dose Escalation of ArtemiCoffee (clinicaltrials.gov)
    P1, N=18, Recruiting, Jill M Kolesar | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
    Trial completion date • Trial primary completion date • Metastases
    |
    CD99 (CD99 Molecule) • ABCF2 (ATP Binding Cassette Subfamily F Member 2)
    over2years
    Exploring the Shared Gene Signatures and Molecular Mechanisms between Bladder Urothelial Carcinoma and Metabolic Syndrome. (PubMed, Arch Esp Urol)
    The interaction of BLCA with MS may be associated with several cancer pathways being activated and identified TAF10 and ABCF2 as potential biomarkers and therapeutic targets for patients with BLCA and MS.
    Journal • Gene Signature
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    ABCF2 (ATP Binding Cassette Subfamily F Member 2) • TAF1 (TATA-Box Binding Protein Associated Factor 1)
    over3years
    DNA Copy Number Aberrations and Expression of ABC Transporter Genes in Breast Tumour: Correlation with the Effect of Neoadjuvant Chemotherapy and Prognosis of the Disease. (PubMed, Pharmaceutics)
    The study showed that the aberrant state of ABC transporter genes, as well as a decrease in the expression of these genes, is a predictor of the effectiveness of therapeutic treatment and a potential prognostic marker of metastatic survival.
    Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCC2 (ATP Binding Cassette Subfamily C Member 2) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • ABCF2 (ATP Binding Cassette Subfamily F Member 2)