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    GENE:

    ABCE1 (ATP Binding Cassette Subfamily E Member 1)

    i
    Other names: ABCE1, ATP Binding Cassette Subfamily E Member 1, RLI, RNASEL1, RNASELI, RNS4I, OABP, RLI1, ATP-Binding Cassette, Sub-Family E (OABP), Member 1, ATP-Binding Cassette Sub-Family E Member 1, 2’-5’-Oligoadenylate-Binding Protein, Ribonuclease 4 Inhibitor, RNase L Inhibitor 1, HuHP68, Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) Inhibitor, RNase L Inhibitor, ABC38
    Associations

    News

    Trials
    14d
    Profound alterations of cancer transcriptomes by the RNase L inhibitor ABCE1 through the modulation of UU/UA-dinucleotide rich transcript abundance. (PubMed, RNA Biol)
    In lung cancer ABCE1 overexpression is milder and is associated with poor survival. We report a measurable, specific, and extensive modulation of cancer transcriptomes by the oncogenic overexpression of a component of interferon signalling with unexpected outcomes on patient survival.
    Journal
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    ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    19d
    Retraction Note. (PubMed, Eur Rev Med Pharmacol Sci)
    These articles have been retracted. The Publisher apologizes for any inconvenience this may cause.
    Journal
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    NOTCH1 (Notch 1) • TNFA (Tumor Necrosis Factor-Alpha) • S100A8 (S100 Calcium Binding Protein A8) • FOXP1 (Forkhead Box P1) • MMP9 (Matrix metallopeptidase 9) • GAS5 (Growth Arrest Specific 5) • SNAI1 (Snail Family Transcriptional Repressor 1) • MIR183 (MicroRNA 183) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    1m
    Metabolome and transcriptome analyses provide insights into the podophyllotoxin content difference in different Sinopodophyllum hexandrum provenances. (PubMed, Front Plant Sci)
    The results showed that deoxypodophyllotoxin synthase (2-ODD), secoisolariciresinol dehydrogenase (SDH) and coumarate 3-hydroxylase (C3H) were essential genes that lead to the PTOX content differences in S. hexandrum from different provenances, WRKY and AP2/ERF-ERF were considered to be key transcription factors, and ABCE1 and ABCC2 were the primary transporters. The results can provide a new perspective and excellent genes for revealing the cause of the different PTOX contents in S. hexandrum from different provenances.
    Journal
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    ABCC2 (ATP Binding Cassette Subfamily C Member 2) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    5ms
    LTO1 and YAE1 regulate MHC-I expression via nonsense-mediated RNA decay in tumor cells. (PubMed, J Immunother Cancer)
    Collectively, our findings establish novel roles for the LTO1/YAE1 complex in regulating MHC-I expression via NMD. As MHC-I is crucial for antigen presentation and T cell activation, these results reveal a previously unappreciated link between NMD and tumor immunogenicity, with potential implications for cancer immunotherapies.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • IRF1 (Interferon Regulatory Factor 1) • NLRC5 (NLR Family CARD Domain Containing 5) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    8ms
    ABCE1 facilitates tumour progression via aerobic glycolysis and inhibits cell death in human colorectal cancer cells through the p53 signalling pathway. (PubMed, Sci Rep)
    Overall, the findings from this study underscore the importance of ABCE1 as a potential biomarker in CRC and illuminate its complex molecular mechanisms. The demonstrated effectiveness of ABCE1 inhibition, particularly through irinotecan, coupled with its interplay with crucial signalling pathways such as p53, highlights its potential as a promising therapeutic option for colorectal cancer treatment.
    Journal
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    ABCE1 (ATP Binding Cassette Subfamily E Member 1)
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    irinotecan
    over1year
    The association of ABC proteins with multidrug resistance in cancer. (PubMed, Biochim Biophys Acta Mol Cell Res)
    We further discussed that the most commonly used drugs in standard regimens for mainly breast cancer, lung cancer, and acute lymphoblastic leukemia could be subject to MDR mediated by ABC transporters. Collectively, these insights will aid in conducting new studies aimed at a deeper understanding of the clinical MDR mediated by ABC proteins and in designing more effective pharmacological treatments to enhance the objective response rate in cancer patients.
    Review • Journal
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    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • ABCC10 (ATP Binding Cassette Subfamily C Member 10) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • ABCF2 (ATP Binding Cassette Subfamily F Member 2) • ABCG1 (ATP Binding Cassette Subfamily G Member 1) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    over1year
    Translation stalling induced mitochondrial entrapment of ribosomal quality control related proteins offers cancer cell vulnerability. (PubMed, Res Sq)
    Our study highlights the significance of mitochondrial entrapment of RQC factors such as ABCE1 in determining the fate of cancer cells versus CSCs. Targeting ABCE1 or other RQC factors in translational inhibition cancer therapy may help overcome drug resistance.
    Journal
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    ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    over1year
    Ribosome stalling during c-myc translation presents actionable cancer cell vulnerability. (PubMed, PNAS Nexus)
    Remarkably, Nsp1 exhibits synthetic toxicity with the translation and RQC-related factor ATP-binding cassette subfamily E member 1, which, despite its normally positive correlation with cMyc in cancer cells, is co-opted by Nsp1 to down-regulate cMyc and inhibit tumor growth. Ribosome stalling during c-myc translation thus offers actionable cancer cell vulnerability.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    almost2years
    Molecular analysis to identify novel potential biomarkers as drug targets in colorectal cancer therapy: an integrated bioinformatics analysis. (PubMed, Mol Cell Oncol)
    Finally, our integrated bioinformatic analysis revealed that ABCE1, AURKA, HSPD1, PHKA1, CDK4, and YWHAE as hub genes with potential oncogenic roles in CRC. These genes hold promise as diagnostic and prognostic markers for colorectal tumorigenesis, providing insights into targeted therapies for improved patient outcomes.
    Journal
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    CDK4 (Cyclin-dependent kinase 4) • AURKA (Aurora kinase A) • HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    almost2years
    Identification of biomimetic nanoplatform-mediated delivery of si-ISG15 for treatment of triple-negative breast cancer. (PubMed, Cell Signal)
    Furthermore, we created a nanoparticle-based siRNA camouflaged using a cancer cell membrane vesicle delivery system (the CM@NP complex) and confirmed its therapeutic effects in vivo. Our findings confirmed that ISG15 may play a pivotal oncogenic role in the development of TNBC and that CM@siRNA-NP complexes are an effective delivery system and a novel biological strategy for treating TNBC.
    Journal
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    ISG15 (ISG15 Ubiquitin Like Modifier) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    almost2years
    Restoration of miR-299-3p promotes macrophage phagocytosis and suppresses malignant phenotypes in breast cancer carcinogenesis via dual-targeting CD47 and ABCE1. (PubMed, Int Immunopharmacol)
    In vivo BC xenografts based on nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice further proved that restoration of miR-299-3p resulted in a significant suppression of tumorigenesis and a promotion of macrophage activation and infiltration. Overall, our study suggested that miR-299-3p is a potent inhibitor of CD47 and ABCE1 to exhibit bifunctional BC-suppressing effects through immune activation conjugated with malignant behavior inhibition in breast carcinogenesis and thus can potentially serve as a novel therapeutic target for BC.
    Journal
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    CD47 (CD47 Molecule) • SIRPA (Signal Regulatory Protein Alpha) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)
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    CD47 expression
    over2years
    miR-3200 accelerates the growth of liver cancer cells by enhancing Rab7A. (PubMed, Noncoding RNA Res)
    Furthermore, our results suggest that miR-3200 enhances expression of RAB7A, and then Rab7A regulates the carcinogenic function of miR-3200 by increasing telomere remodeling in human liver cancer. These results are of great significance for the prevention and treatment of human liver cancer.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • CCND1 (Cyclin D1) • SQSTM1 (Sequestosome 1) • PIM1 (Pim-1 Proto-Oncogene) • RAD54L (DNA Repair And Recombination Protein RAD54) • ARAF (A-Raf Proto-Oncogene) • PCNA (Proliferating cell nuclear antigen) • ANXA6 (Annexin A6) • CDK1 (Cyclin-dependent kinase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • HOXC8 (Homeobox C8) • HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A) • MIR3200 (MicroRNA 3200) • PLK2 (Polo Like Kinase 2) • BECN1 (Beclin 1) • CDC45 (Cell Division Cycle 45) • FBXO32 (F-Box Protein 32) • FZD3 (Frizzled Class Receptor 3) • ITGB5 (Integrin Subunit Beta 5) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • PKM (Pyruvate Kinase M1/2) • RAB7A (RAB7A, Member RAS Oncogene Family) • SUV39H1 (SUV39H1 Histone Lysine Methyltransferase) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)