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    GENE:

    ABCC11 (ATP Binding Cassette Subfamily C Member 11)

    i
    Other names: ABCC11, ATP Binding Cassette Subfamily C Member 11, ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 11, ATP-Binding Cassette Sub-Family C Member 11, Multidrug Resistance-Associated Protein 8, MRP8, ATP-Binding Cassette Transporter Sub-Family C Member 11, ATP-Binding Cassette Transporter MRP8, ATP-Binding Cassette Protein C11, Multi-Resistance Protein 8, EWWD, WW
    3ms
    ABCB1 and ABCC10 polymorphisms predict sensitivity to first- and third-generation EGFR-TKIs in EGFR-mutant NSCLC. (PubMed, Invest New Drugs)
    To assess clinical relevance, blood samples from 109 gefitinib/erlotinib- and 54 osimertinib-treated patients were analyzed for these SNPs. These findings suggest that ABC transporter SNPs could be valuable biomarkers for personalized medicine in NSCLC. These findings suggest that ABC transporter SNPs may serve as valuable biomarkers for predicting EGFR-TKI efficacy in NSCLC patients with EGFR mutations, which will contribute to personalized medicine.
    Journal
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    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ABCC10 (ATP Binding Cassette Subfamily C Member 10) • ABCC11 (ATP Binding Cassette Subfamily C Member 11)
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    EGFR mutation • EGFR expression
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    Tagrisso (osimertinib) • erlotinib • gefitinib
    5ms
    An Emerging Paradigm for ABCC5/MRP5 Function in Human Physiology. (PubMed, Int J Mol Sci)
    However, this review emphasises caution in targeting ABCC5 for cancer therapy due to its underappreciated physiological function(s), particularly in the brain and male reproductive system. Understanding ABCC5's substrate specificity, regulatory mechanisms, and functional redundancy with its paralog ABCC12 remains critical for successful therapeutic strategies in humans.
    Review • Journal
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    ABCC2 (ATP Binding Cassette Subfamily C Member 2) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • ABCC5 (ATP Binding Cassette Subfamily C Member 5)
    12ms
    In silico identification of multidrug resistance gene (MDR)-targeted transposon miRNAs in human cancer. (PubMed, Mutat Res)
    Multidrug resistance (MDR) in cancer is often associated with overexpression of ABC transporter proteins, which can lead to failure of cancer treatments. Additionally, the relationship of miRNAs with ABC transporter proteins constitutes an important research area to understand the mechanisms of drug resistance and develop new treatment strategies.
    Journal
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    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ABCC10 (ATP Binding Cassette Subfamily C Member 10) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • ABCC3 (ATP Binding Cassette Subfamily C Member 3)
    1year
    The analysis of gene co-expression network and immune infiltration revealed biomarkers between triple-negative and non-triple negative breast cancer. (PubMed, Front Genet)
    Particularly intriguing discovery emerged with respect to the transcription factor FOXM1, which demonstrated a significant regulatory role in genes positively correlated with the proportions of M0 and M1 macrophages, while displaying a negative correlation with the proportion of M2 macrophages in breast cancer tissue. Our research provides new insight into the biomarkers and immune infiltration of TNBC, which could be useful for clinical diagnosis of TNBC.
    Journal
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    FOXM1 (Forkhead Box M1) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • ABCA1 (ATP Binding Cassette Subfamily A Member 1)
    almost2years
    Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor. (PubMed, Hum Cell)
    Among them, p.R630W was most influential. Including this identification of a significantly-dysfunctional variant, our findings will extend our understanding of genetic variations and biochemical features of ABCC11 protein.
    Journal
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    ABCC11 (ATP Binding Cassette Subfamily C Member 11)
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    ABCC11 expression
    almost2years
    BAG3 regulates cilia homeostasis of glioblastoma via its WW domain. (PubMed, Biofactors)
    BAG3 depletion reduced activation of a YAP1/AURKA signaling pathway and induction of PLK1. Collectively, our findings point to a complex interaction network of BAG3 with several pathways regulating cilia homeostasis, involving processes related to ciliogenesis and cilium degradation.
    Journal
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    YAP1 (Yes associated protein 1) • AURKA (Aurora kinase A) • PLK1 (Polo Like Kinase 1) • SOX2 • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • OLIG2 (Oligodendrocyte Transcription Factor 2)
    almost2years
    The role of telocytes and miR-21-5p in tumorigenicity and metastasis of breast cancer stem cells. (PubMed, Mol Biol Rep)
    In our study, by gene/protein level analysis we demonstrated that telocytes may have the potential to reduce cancer metastasis through miR-21-5p in breast cancer progression and reduce EMT transition.
    Journal • Cancer stem
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    MIR21 (MicroRNA 21) • VIM (Vimentin) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • CDH2 (Cadherin 2) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • SNAI1 (Snail Family Transcriptional Repressor 1) • LZTFL1 (Leucine Zipper Transcription Factor Like 1)
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    VIM expression • miR-21 expression • ABCC11 expression
    almost3years
    Pharmacogenetics of the Primary and Metastatic Osteosarcoma: Gene Expression Profile Associated with Outcome. (PubMed, Int J Mol Sci)
    In addition, the expression of the ABCC10, GGH, GSTM3 and SLC22A1 genes were associated with the disease event, and the metastasis specimens showed a high expression profile of ABCC1, ABCC3 and ABCC4 genes and a low expression of SLC22A1 and ABCC10 genes, which is possibly an important factor for resistance in OS metastasis. Therefore, our findings may, in the future, contribute to clinical management as prognostic factors as well as possible therapeutic targets.
    Journal • Gene Expression Profile • Metastases
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    TOP2A (DNA topoisomerase 2-alpha) • MSH2 (MutS Homolog 2) • BCL2L1 (BCL2-like 1) • ERCC1 (Excision repair cross-complementation group 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • GSTP1 (Glutathione S-transferase pi 1) • FASLG (Fas ligand) • MTHFR (Methylenetetrahydrofolate Reductase) • CASP3 (Caspase 3) • ABCC2 (ATP Binding Cassette Subfamily C Member 2) • ABCC10 (ATP Binding Cassette Subfamily C Member 10) • SLC22A1 (Solute Carrier Family 22 Member 1) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • ABCC3 (ATP Binding Cassette Subfamily C Member 3) • ABCC5 (ATP Binding Cassette Subfamily C Member 5) • ABCC6 (ATP Binding Cassette Subfamily C Member 6)
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    TOP2A expression
    over3years
    DNA Copy Number Aberrations and Expression of ABC Transporter Genes in Breast Tumour: Correlation with the Effect of Neoadjuvant Chemotherapy and Prognosis of the Disease. (PubMed, Pharmaceutics)
    The study showed that the aberrant state of ABC transporter genes, as well as a decrease in the expression of these genes, is a predictor of the effectiveness of therapeutic treatment and a potential prognostic marker of metastatic survival.
    Journal
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    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCC2 (ATP Binding Cassette Subfamily C Member 2) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • ABCF2 (ATP Binding Cassette Subfamily F Member 2)
    almost4years
    Adenosine triphosphate-binding cassette subfamily C members in liver hepatocellular carcinoma: Bioinformatics-driven prognostic value. (PubMed, Medicine (Baltimore))
    None showed prognostic significance for microvascular invasion (P < .05).We identified ABCC1/2/3/4/5/6/9/10/11 as potential diagnostic markers, and ABCC1/4/5/6/7/8/9/12/13 as prognostic markers, of LIHC. Our future work will promote the use of ABCCs in the diagnosis and treatment of LIHC.
    Journal
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    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • ABCC2 (ATP Binding Cassette Subfamily C Member 2) • ABCC10 (ATP Binding Cassette Subfamily C Member 10) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • ABCC3 (ATP Binding Cassette Subfamily C Member 3) • ABCC5 (ATP Binding Cassette Subfamily C Member 5)
    almost4years
    CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancer. (PubMed, Biomed Pharmacother)
    We further showed that CDX2 directly regulates the expression of ABCC11 and that the inhibition of ABCC11 improves 5-FU-sensitivity of CDX2-expressing colon cancer cells. Thus, this study illustrates how biological functions are hijacked in CRC cells and reveals the therapeutic interest of CDX2/ABCC11/DPYD to improve systemic chemotherapy in CRC.
    Clinical • Journal
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    CDX2 (Caudal Type Homeobox 2) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • DPYD (Dihydropyrimidine Dehydrogenase)
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    CDX-2 expression • ABCC11 expression
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    5-fluorouracil