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    BIOMARKER:

    ABCC11 expression

    i
    Other names: ABCC11, ATP Binding Cassette Subfamily C Member 11, ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 11, ATP-Binding Cassette Sub-Family C Member 11, Multidrug Resistance-Associated Protein 8, MRP8, ATP-Binding Cassette Transporter Sub-Family C Member 11, ATP-Binding Cassette Transporter MRP8, ATP-Binding Cassette Protein C11, Multi-Resistance Protein 8, EWWD, WW
    Entrez ID:
    85320
    Related biomarkers:
    Others
    Associations

    News

    Trials
    3d
    Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor. (PubMed, Hum Cell)
    Among them, p.R630W was most influential. Including this identification of a significantly-dysfunctional variant, our findings will extend our understanding of genetic variations and biochemical features of ABCC11 protein.
    Journal
    |
    ABCC11 (ATP Binding Cassette Subfamily C Member 11)
    |
    ABCC11 expression
    2ms
    The role of telocytes and miR-21-5p in tumorigenicity and metastasis of breast cancer stem cells. (PubMed, Mol Biol Rep)
    In our study, by gene/protein level analysis we demonstrated that telocytes may have the potential to reduce cancer metastasis through miR-21-5p in breast cancer progression and reduce EMT transition.
    Journal • Cancer stem
    |
    MIR21 (MicroRNA 21) • VIM (Vimentin) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • CDH2 (Cadherin 2) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • SNAI1 (Snail Family Transcriptional Repressor 1) • LZTFL1 (Leucine Zipper Transcription Factor Like 1)
    |
    VIM expression • miR-21 expression • ABCC11 expression
    1year
    WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein. (PubMed, Cell Commun Signal)
    Our results define the WWP2-LATS1 axis as a critical regulatory mechanism of the Hippo-YAP1 pathway that promotes GC development and progression. Video Abstract.
    Journal
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    YAP1 (Yes associated protein 1) • LATS1 (Large Tumor Suppressor Kinase 1) • WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2)
    |
    ABCC11 expression
    2years
    CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancer. (PubMed, Biomed Pharmacother)
    We further showed that CDX2 directly regulates the expression of ABCC11 and that the inhibition of ABCC11 improves 5-FU-sensitivity of CDX2-expressing colon cancer cells. Thus, this study illustrates how biological functions are hijacked in CRC cells and reveals the therapeutic interest of CDX2/ABCC11/DPYD to improve systemic chemotherapy in CRC.
    Clinical • Journal
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    CDX2 (Caudal Type Homeobox 2) • ABCC11 (ATP Binding Cassette Subfamily C Member 11) • DPYD (Dihydropyrimidine Dehydrogenase)
    |
    CDX-2 expression • ABCC11 expression
    |
    5-fluorouracil
    over3years
    Expression of ATP-binding Cassette Transporter 11 (ABCC11) Protein in Colon Cancer. (PubMed, Anticancer Res)
    There was significant correlation with ABCC11 expression and lymph node metastasis, venous invasion and curability. The prognosis in ABCC11 negative cases was poor because of increased cases without curative resection.
    Retrospective data • Journal
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    ABCC11 (ATP Binding Cassette Subfamily C Member 11)
    |
    ABCC11 expression
    |
    fluorouracil topical