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BIOMARKER:

ABCC1 expression

i
Other names: ATP Binding Cassette Subfamily C Member 1, ATP-binding cassette, sub-family C (CFTR/MRP), member 1, GS-X, MRP, MRP1, ABCC1
Entrez ID:
Related biomarkers:
4d
Mechanisms of lipopolysaccharide protection in tumor drug-induced macrophage damage. (PubMed, Int J Biol Macromol)
Furthermore, three inhibitors (inhibitors of GST, glutathione synthesis, and ABCC1) were used for further investigation, showing that these inhibitors reduced macrophage survival rates by 44.0 %, 52.3 %, and 43.3 %, while the intracellular adriamycin content increased by 28.9 %, 42.9 %, and 51.3 %, respectively. These findings suggest that the protective mechanism of LPS on macrophages is associated with increased GST activity, the consumption of glutathione, and increased expression of ABCC1 protein. Therefore, LPS has a potential role in enhancing immunity.
Journal
|
ABCC1 (ATP Binding Cassette Subfamily C Member 1) • GSTP1 (Glutathione S-transferase pi 1) • GSTT1 (Glutathione S-transferase theta 1)
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ABCC1 expression
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doxorubicin hydrochloride
10d
Overexpression of multidrug resistance-associated protein 1 protects against cardiotoxicity by augmenting the doxorubicin efflux from cardiomyocytes. (PubMed, J Gene Med)
Finally, we demonstrated that hiPSC-CM transduced with LV.MRP1 were protected against doxorubicin injury. In conclusion, we have shown that we can successfully overexpress MRP1 protein in hiPSC-CM, with functional transporter activity leading to protection against doxorubicin-induced toxicity.
Journal
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ABCC1 (ATP Binding Cassette Subfamily C Member 1)
|
ABCC1 expression • ABCC1 overexpression
|
doxorubicin hydrochloride
2ms
Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker. (PubMed, Transl Oncol)
Furthermore, various in vitro and in vivo experiments substantiated the role of ABCC1 in promoting the progression of HCC, along with increased macrophage recruitment. Based on the results, we propose ABCC1 as a potentially valuable prognostic indicator and a prospective target for immune-based cancer therapies.
Journal • Pan tumor
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ABCC1 (ATP Binding Cassette Subfamily C Member 1)
|
ABCC1 expression • ABCC1 overexpression
2ms
Emerging roles of ncRNAs regulating ABCC1 on chemotherapy resistance of cancer - a review. (PubMed, J Chemother)
A growing number of studies have shown that ncRNAs have effects on cancer cell proliferation, invasion, metastasis, and drug sensitivity, by regulating the expression of ABCC1. In this review, we will discuss the emerging roles of ncRNAs regulating ABCC1 in chemotherapy resistance and mechanisms to reverse drug resistance as well as provide potential targets for future cancer treatment.
Review • Journal
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ABCC1 (ATP Binding Cassette Subfamily C Member 1)
|
ABCC1 expression
3ms
Macrophages enhance cisplatin resistance in gastric cancer through the transfer of circTEX2. (PubMed, J Cell Mol Med)
qRT-PCR, RNAase R assay, actinomycin D assay and cell nucleo-cytoplasmic separation experiments confirmed the existence of circTEX2 in macrophage cytoplasm, with a higher expression level in M2 macrophages than that in M1 macrophages. In conclusion, our research suggests that the exosomal transfer of M2 macrophage-derived circTEX2 enhances cisplatin resistance in gastric cancer through miR-145/ABCC1. Additionally, communication between macrophages and cancer cells via exosomes may be a promising therapeutic target for the treatment of cisplatin-resistant gastric cancer.
Journal
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ABCC1 (ATP Binding Cassette Subfamily C Member 1) • MIR145 (MicroRNA 145)
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ABCC1 expression
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cisplatin • dactinomycin
4ms
Methylation of PLK-1 Potentially Drives Bendamustine Resistance in Leukemia Cells. (PubMed, J Nippon Med Sch)
Our findings indicate that the methylation of the PLK-1 gene plays a pivotal role in modulating PLK-1 expression and is central to the development of bendamustine resistance in leukemia cells.
Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • PLK1 (Polo Like Kinase 1)
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ABCC1 expression
|
bendamustine
4ms
Restoring microRNA-34a overcomes acquired drug resistance and disease progression in human breast cancer cell lines via suppressing the ABCC1 gene. (PubMed, Breast Cancer Res Treat)
The ectopic expression of miRNA-34a ameliorates the acquired drug resistance and the migration properties that may eventually lead to improved clinical strategies and outcomes for breast cancer patients. Additionally, miRNA-34a could be monitored as a diagnostic/prognostic biomarker for resistant conditions.
Preclinical • Journal
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ABCC1 (ATP Binding Cassette Subfamily C Member 1) • MIR34A (MicroRNA 34a-5p)
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ABCC1 expression
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doxorubicin hydrochloride
5ms
The role and impact of alternative polyadenylation and miRNA regulation on the expression of the multidrug resistance-associated protein 1 (MRP-1/ABCC1) in epithelial ovarian cancer. (PubMed, Sci Rep)
We showed that we could induce ferroptosis and sensitize the cisplatin resistant cells to cisplatin by using erastin. Knocking down ABCC1 resulted in decreased cell viability, but did not contribute to erastin induced ferroptosis.
Journal
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ABCC1 (ATP Binding Cassette Subfamily C Member 1) • miR-185 (MicroRNA 185) • MIR326 (MicroRNA 326)
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ABCC1 expression
|
cisplatin • erastin
9ms
Interaction of pregnane X receptor with hypoxia-inducible factor-1 regulates chemoresistance of prostate cancer cells. (PubMed, Cancer Drug Resist)
Co-immunoprecipitation results showed that HIF-1 and PXR could physically interact with each other, leading to crosstalk between these two transcription factors. PXR contributes to hypoxia-induced drug resistance in prostate cancer cells through its interaction with HIF-1.
Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • ABCC1 (ATP Binding Cassette Subfamily C Member 1)
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ABCC1 expression • HIF1A expression
10ms
Bixin and Fuxoxanthin Alone and in Combination with Cisplatin Regulate ABCC1 and ABCC2 Transcription in A549 Lung Cancer Cells. (PubMed, J Pharm Bioallied Sci)
The administration of bixin or fucoxanthin decreases the expression of ABCC1 and ABCC2. Both carotenoids, either alone or in combination with cisplatin, upregulated p53 gene expression indicating the mechanism of proliferation inhibition and apoptosis occurs via the p53 caspase-independent pathway.
Journal • Combination therapy
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • ABCC2 (ATP Binding Cassette Subfamily C Member 2) • ABCC3 (ATP Binding Cassette Subfamily C Member 3)
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ABCB1 overexpression • TP53 expression • ABCC1 expression
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cisplatin
11ms
ABCC1 is a predictive biomarker for prognosis and therapy in hepatocellular carcinoma. (PubMed, Eur Rev Med Pharmacol Sci)
Our study identified ABCC1 as a predictor of HCC prognosis and response to therapy.
Journal
|
ABCC1 (ATP Binding Cassette Subfamily C Member 1)
|
ABCC1 expression
11ms
Circ-ABCC1 enhances radioresistance of breast cancer cells via miR-627-5p/ABCC1 axis. (PubMed, Cell Mol Biol (Noisy-le-grand))
Rescue assays uncovered that the suppressive impact of circ-ABCC1 silence on BC cell radio-resistance was allowed to be antagonized by miR-627-5p inhibition or ABCC1 up-regulation. In conclusion, Circ-ABCC1 aggravates the radioresistance of BC cells by targeting the miR-627-5p/ABCC1 axis.
Journal
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ABCC1 (ATP Binding Cassette Subfamily C Member 1) • CASP3 (Caspase 3)
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ABCC1 expression
almost1year
Effect of Polyunsaturated Fatty Acids on Temozolomide Drug-Sensitive and Drug-Resistant Glioblastoma Cells. (PubMed, Biomedicines)
GLA and EPA in combination with TMZ caused significant reductions in rhodamine 123 efflux from U87MG cells but not from TMZR cells. Overall, these findings support the notion that PUFAs can modulate ABC transporters in GBM cells.
Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCC1 (ATP Binding Cassette Subfamily C Member 1)
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ABCC1 expression
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temozolomide
1year
Overcoming acquired resistance to PROTAC degraders (AACR 2023)
Our study found that the mechanisms of resistance of PROTAC degraders can vary and may be dependent on drug concentrations. Such concepts may inform future clinical decision-making regarding drug dosing.
Preclinical
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PBRM1 (Polybromo 1) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCC1 (ATP Binding Cassette Subfamily C Member 1)
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ABCB1 overexpression • ABCB1 expression • ABCC1 expression
|
AU-15330
1year
Evaluation of multidrug resistant genes among breast cancer patients in Ghana (AACR 2023)
ABCC1 has been established to be associated with African ancestry. Determining the association of ABC gene SNPs and MDR among Ghanaian BC patients will provide further information on allelic variants and their effects on BC treatment outcomes.
Clinical
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ABCC1 (ATP Binding Cassette Subfamily C Member 1)
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ABCC1 expression
1year
CircSETDB1 contributes to paclitaxel resistance of ovarian cancer cells by sponging miR-508-3p and regulating ABCC1 expression. (PubMed, Anticancer Drugs)
CircSETDB1 knockdown also enhanced Ptx sensitivity in vivo. In conclusion, circSETDB1 regulated Ptx resistance of ovarian cancer by targeting miR-508-3p/ABCC1 axis.
Journal
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ABCC1 (ATP Binding Cassette Subfamily C Member 1) • MIR508 (MicroRNA 508) • SETDB1 (SET Domain Bifurcated Histone Lysine Methyltransferase 1)
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ABCC1 expression • ABCC1 overexpression
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paclitaxel
1year
The ferroptosis signature predicts the prognosis and immune microenvironment of nasopharyngeal carcinoma. (PubMed, Sci Rep)
Moreover, the NPC patients with high risk were sensitive to chemotherapeutic drugs including axitinib, docetaxel, embelin, epothilone.B, parthenolide, thapsigargin, tipifarnib, vinorelbine. Finally, the expression of ABCC1 and GLS2 was validated in NPC tissues using immunohistochemistry. Together, these results revealed ferroptosis may be a potential biomarker in NPC and representing a promising future direction in prognosis and therapeutic strategy for the treatment of NPC.
Journal
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ABCC1 (ATP Binding Cassette Subfamily C Member 1)
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ABCC1 expression
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docetaxel • Zarnestra (tipifarnib) • Inlyta (axitinib) • vinorelbine tartrate • patupilone (EPO 906)
over1year
Prrx1 promotes resistance to temozolomide by upregulating ABCC1 and inducing vasculogenic mimicry in glioma. (PubMed, Am J Cancer Res)
Collectively, our findings supported the critical role of Prrx1 in TMZ resistance via intrinsic and extrinsic mechanism. Targeting Prrx1 might represent a feasible strategy to overcome therapeutic resistance in glioma.
Journal
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ABCC1 (ATP Binding Cassette Subfamily C Member 1) • PRRX1 (Paired Related Homeobox 1)
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ABCC1 expression
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temozolomide
over1year
Circular RNA circ-CD44 regulates chemotherapy resistance by targeting the miR-330-5p/ABCC1 axis in colorectal cancer cells. (PubMed, Histol Histopathol)
Mechanistically, circ-CD44 functioned as a miRNA sponge for miR-330-5p to upregulate the expression of ABCC1 and regulate chemotherapy resistance in CRC cells.
Journal
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CD44 (CD44 Molecule) • ABCC1 (ATP Binding Cassette Subfamily C Member 1)
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ABCC1 expression • CD44 expression
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oxaliplatin
over1year
Isothiocyanates (ITCs) 1-(Isothiocyanatomethyl)-4-phenylbenzene and 1-Isothiocyanato-3,5-bis(trifluoromethyl)benzene-Aldehyde Dehydrogenase (ALDH) Inhibitors, Decreases Cisplatin Tolerance and Migratory Ability of NSCLC. (PubMed, Int J Mol Sci)
The present study compares the anticancer properties of 36 structurally diverse isothiocyanates (ITCs) against NSCLC cells with the ALDH inhibitor disulfiram (DSF). Furthermore, long-term supplementation with ITC 1-(isothiocyanatomethyl)-4-phenylbenzene reverses the EMT phenotype and migratory potential of A549CisR to the level presented by parental A549 cells, increasing E-Cadherin expression, followed by decreased expression of ABCC1 and ALDH3A1. Our data indicates that the ALDH inhibitors DSF and ITCs are potential adjuvants of cisplatin chemotherapy.
Journal
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CDH1 (Cadherin 1) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • ALDH3A1 (Aldehyde Dehydrogenase 3 Family Member A1)
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ABCC1 expression • CDH1 expression
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cisplatin
over1year
High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation. (PubMed, Cell Death Dis)
Two human glioblastoma cell lines (U251MG and T98G) were examined after treatment with TMZ, ferroptosis inducers (Erastin, RSL3), and ferroptosis inhibitor (Ferrostatin-1). Altogether, our data indicate that high levels of NRF2 result in collateral sensitivity on glioblastoma via the expression of its pro-ferroptotic target ABCC1, which contributes to GSH depletion when the system xc is blocked by Erastin. Thus, ferroptosis induction could be an important therapeutic strategy to reverse drug resistance in gliomas with high NRF2 and ABCC1 expression.
Journal
|
NFE2L2 (Nuclear Factor, Erythroid 2 Like 2) • ABCC1 (ATP Binding Cassette Subfamily C Member 1)
|
ABCC1 expression
|
temozolomide • erastin • RSL3
almost2years
Upregulation of USP22 and ABCC1 during Sorafenib Treatment of Hepatocellular Carcinoma Contribute to Development of Resistance. (PubMed, Cells)
Immunohistochemical analysis revealed a positive correlation between USP22 and ABCC1 expression in tissue samples from sorafenib-resistant patients (Pearson's correlation = 0.59, p = 0.03). Our findings indicate that upregulation of USP22 and ABCC1 expression during treatment contribute to sorafenib resistance in HCC cells and that USP22 has strong potential as a therapeutic target for overcoming sorafenib resistance in HCC patients.
Journal
|
ABCC1 (ATP Binding Cassette Subfamily C Member 1) • USP22 (Ubiquitin Specific Peptidase 22)
|
ABCC1 expression
|
sorafenib
almost2years
SUMOylation of METTL3 facilitates CRC progression by promoting circ_0000677 to regulate ABCC1 in an m6A-dependent manner. (PubMed, J Gastroenterol Hepatol)
Overall, our study revealed that circ_0000677 and its downstream target ABCC1 were upregulated in CRC cells, induced by the METTL3-mediated m A modification of circ_0000677 and SUMO1-mediated SUMOylation of METTL3. This work provided a new strategy for the therapeutic treatment of CRC.
Journal
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ABCC1 (ATP Binding Cassette Subfamily C Member 1) • METTL3 (Methyltransferase Like 3)
|
ABCC1 expression
almost2years
Stress hormone norepinephrine incites resistance of oral cancer cells to chemotherapy. (PubMed, Endocr Relat Cancer)
Head and neck SCC-derived cell lines SCC-9, Cal27, SCC-25, and FaDu were stimulated with NE or E and treated with the inhibitory concentration of cisplatin for 24 h. As for adrenergic receptors (ADRB) inhibition, cells were treated with propranolol. Migratory activity of oral SCC cells challenged with cisplatin was not affected by norepinephrine. These findings reveal for the first time that stress hormone norepinephrine induce resistance of oral cancer cells to cisplatin in vitro through the ADRB/Akt/ABCG2 pathway, pumping the drug out of the cell and inhibiting apoptosis.
Journal • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • CASP3 (Caspase 3)
|
BCL2 expression • ABCC1 expression
|
cisplatin
almost2years
Transferrin Coated d-penicillamine-Au-Cu Nanocluster PLGA Nanocomposite Reverses Hypoxia-Induced EMT and MDR of Triple-Negative Breast Cancers. (PubMed, ACS Appl Bio Mater)
Importantly, nanocomposites downregulated the expression of β-catenin by 3-fold in MDA-MB-231 and by 3.11-fold in MDA-MB-468. Downregulation of EMT with concomitant alteration of STAT-3 and β-catenin signaling pathways led to reduced migration ability of the TNBC cells.
Journal
|
CDH1 (Cadherin 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • EPCAM (Epithelial cell adhesion molecule) • VIM (Vimentin)
|
ABCC1 expression
almost2years
Clinical Significance and Potential Mechanisms of ATP Binding Cassette Subfamily C Genes in Hepatocellular Carcinoma. (PubMed, Front Genet)
In conclusion, ABCC1, ABCC4, ABCC5, and ABCC6 might be prognostic biomarkers in HCC. The prognostic models constructed with ABCC1, ABCC4, ABCC5, and ABCC6 had satisfactory efficacy.
Journal
|
ABCC1 (ATP Binding Cassette Subfamily C Member 1) • ABCC10 (ATP Binding Cassette Subfamily C Member 10) • KRT19 (Keratin 19) • ABCC4 (ATP Binding Cassette Subfamily C Member 4) • ABCC5 (ATP Binding Cassette Subfamily C Member 5) • E2F1 (E2F transcription factor 1)
|
ABCC1 expression
over2years
CSMD1 Mutation Related to Immunity Can Be Used as a Marker to Evaluate the Clinical Therapeutic Effect and Prognosis of Patients with Esophageal Cancer. (PubMed, Int J Gen Med)
CSMD1 mutation could be used as an immune-related biomarker to predict prognosis and treatment effect of paclitaxel. Mutation and loss of CSMD1 may promote the progression of ESCA.
Clinical • Journal • Tumor Mutational Burden • PD(L)-1 Biomarker • IO biomarker
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TMB (Tumor Mutational Burden) • PD-1 (Programmed cell death 1) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • CSMD1 (CUB And Sushi Multiple Domains 1)
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TMB-H • TMB-L • PD-1 expression • ABCC1 expression
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paclitaxel
over2years
Identification of circ_0058357 as a regulator in non-small cell lung cancer cells resistant to cisplatin by miR-361-3p/ABCC1 axis. (PubMed, Thorac Cancer)
Our findings identified that inhibition of circ_0058357 suppresses the growth and metastasis of H1299/DDP and A549/DDP cells and sensitizes them to DDP therapy partially by targeting the miR-361-3p/ABCC1 axis.
Journal
|
ABCC1 (ATP Binding Cassette Subfamily C Member 1) • MIR361 (MicroRNA 361)
|
ABCC1 expression
|
cisplatin
over2years
Lysophosphatidate Promotes Sphingosine 1-Phosphate Metabolism and Signaling: Implications for Breast Cancer and Doxorubicin Resistance. (PubMed, Cell Biochem Biophys)
Thus, LPA itself and LPA-induced S1P signaling counteract doxorubicin-induced death of MCF-7 cells. We conclude from the present and previous studies that LPA promotes S1P metabolism and signaling to coordinately increase tumor growth and metastasis and decrease the effectiveness of chemotherapy and radiotherapy for breast cancer treatment.
Journal
|
ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ABCC1 (ATP Binding Cassette Subfamily C Member 1)
|
ABCC1 expression
|
doxorubicin hydrochloride
over2years
Circular RNAcirc_0076305 Promotes Cisplatin (DDP) Resistance of Non-Small Cell Lung Cancer Cells by Regulating ABCC1 Through miR-186-5p. (PubMed, Cancer Biother Radiopharm)
Furthermore, circ_0076305 silencing improved DDP sensitivity of NSCLC in vivo. The results from this study disclosed that circ_0076305 knockdown improved DDP sensitivity by the miR-186-5p/ABCC1 axis in NSCLC, hinting a potential circRNA-targeted therapy for NSCLC.
Journal
|
ABCC1 (ATP Binding Cassette Subfamily C Member 1)
|
ABCC1 expression
|
cisplatin
almost3years
Van der Waals force-driven indomethacin-ss-paclitaxel nanodrugs for reversing multidrug resistance and enhancing NSCLC therapy. (PubMed, Int J Pharm)
Density functional theory (DFT) calculations revealed that the main driving force in self-assembly process was originated from the van der waals force. In addition, this carrier-free nano drug delivery systems (nDDs) could reverse the MDR by downregulating the expression of MRP1 protein in A549/taxol.
Journal
|
ABCC1 (ATP Binding Cassette Subfamily C Member 1)
|
ABCC1 expression
|
paclitaxel
almost3years
Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione. (PubMed, Sci Immunol)
P2RY8 loss-of-function human T cells increased their BM homing. By defining how GGG distribution was determined and identifying sites of P2RY8 activity, this work helps establish how disruptions in P2RY8 function contribute to lymphomagenesis and other disease states.
Journal
|
ABCC1 (ATP Binding Cassette Subfamily C Member 1) • P2RY8 (P2Y Receptor Family Member 8)
|
ABCC1 expression
almost3years
Synergistic Inhibition of Drug-Resistant Colon Cancer Growth with PI3K/mTOR Dual Inhibitor BEZ235 and Nano-Emulsioned Paclitaxel via Reducing Multidrug Resistance and Promoting Apoptosis. (PubMed, Int J Nanomedicine)
These results suggest that nanoemulsion loaded PTX+BEZ235 can overcome drug resistance and improve the inhibitory effect on cancer cell proliferation and tumor growth. Our study thus provides a possible new approach to treat colon cancer patients with drug resistance.
Journal
|
ABCC1 (ATP Binding Cassette Subfamily C Member 1)
|
ABCC1 expression
|
paclitaxel • dactolisib (RTB101)