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    GENE:

    ABCB4 (ATP Binding Cassette Subfamily B Member 4)

    i
    Other names: ABCB4, ATP Binding Cassette Subfamily B Member 4, ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4, ATP-Binding Cassette Sub-Family B Member 4, Phosphatidylcholine Translocator ABCB4, Multidrug Resistance Protein 3, P-Glycoprotein 3, PFIC-3, GBD1, MDR2, MDR3, PGY3, P-Glycoprotein-3/Multiple Drug Resistance-3, Multiple Drug Resistance 3, MDR2/3, ABC21, ICP3
    4d
    Overcoming Immune Exclusion in a Murine Model of Cirrhotic Hepatocellular Carcinoma via Cryoablation: Insights from Molecular Extracellular pH Imaging. (PubMed, Res Sq)
    These results demonstrate that BIRDS enables non-invasive monitoring of the metabolic and immunologic response to cryoablation in HCC within cirrhotic livers. Cryoablation-induced re-normalization of tumor acidity, coupled with enhanced immune activity, suggests a favorable therapeutic outcome and establishes pH e imaging as a tool for assessing treatment efficacy in acidic TMEs.
    Preclinical • Journal
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    ABCB4 (ATP Binding Cassette Subfamily B Member 4)
    4ms
    Leukemia inhibitory factor promotes human cholangiopathies, and its inhibition improves cholestasis in Abcb4-/- mice. (PubMed, Hepatol Commun)
    Cholangiocyte-derived LIF promotes the formation of a pro-inflammatory and pro-fibrotic niche centred on damaged cholangiocytes. LIFR antagonism reverses fibrosis and immune dysregulation in Abcb4-/- mice, supporting the development of anti-LIFR therapies in human cholangiopathies.
    Preclinical • Journal
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    IL6 (Interleukin 6) • LIFR (LIF Receptor Subunit Alpha) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • LIF (LIF Interleukin 6 Family Cytokine)
    4ms
    A Study of TAK-625 for the Treatment of Progressive Familial Intrahepatic Cholestasis (PFIC) (clinicaltrials.gov)
    P3, N=5, Completed, Takeda | Active, not recruiting --> Completed
    Trial completion
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    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCB4 (ATP Binding Cassette Subfamily B Member 4)
    4ms
    Nodosin alleviates cholestatic liver injury by activation of SIRT1/FXR signaling pathway and inhibition of hepatic inflammation. (PubMed, Biochem Pharmacol)
    These findings demonstrate that Nod alleviates cholestasis by activating SIRT1/FXR signaling and down-regulating the NF-κB signaling. Therefore, Nod might be a hopeful therapeutic medicine for cholestasis.
    Journal
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    ABCB4 (ATP Binding Cassette Subfamily B Member 4)
    6ms
    Ion Channel-Extracellular Matrix Interplay in Colorectal Cancer: A Network-Based Approach to Tumor Microenvironment Remodeling. (PubMed, Int J Mol Sci)
    Notably, survival was associated with MAPK1, SLC16A1, and ABCB4 in relation to patient prognosis. Our findings underscore the pivotal role of ion channels as co-factors in ECM dynamics in CRC, offering mechanistic insights into tumor-stroma crosstalk and identifying potential therapeutic targets to disrupt microenvironment-driven progression.
    Journal
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    MAPK1 (Mitogen-activated protein kinase 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • SLC16A1 (Solute Carrier Family 16 Member 1) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • CHST11 (Carbohydrate Sulfotransferase 11) • COL5A2 (Collagen Type V Alpha 2 Chain) • LAMC1 (Laminin Subunit Gamma 1)
    7ms
    Green synthesis an eco-friendly route for the synthesis of iron oxide nanoparticles using aqueous extract of Thevetia peruviana and their biological activities. (PubMed, Sci Rep)
    The NPs also demonstrated notable anticancer activity, particularly against MDR 2780AD (IC₅₀ = 0.39 µg/mL). These results showed significant enzyme inhibition and anticancer properties, indicating the potential of these green-synthesized IONPs in biomedical applications.
    Journal
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    ABCB4 (ATP Binding Cassette Subfamily B Member 4)
    8ms
    Pharmacogenomics in pediatric oncology patients with solid tumors related to chemotherapy-induced toxicity: a systematic review. (PubMed, Crit Rev Oncol Hematol)
    For methotrexate, the genes ABCC2, MTHFR, and SXR were associated with myelosuppression and hepatotoxicity...This review highlights the complexity and variability of pharmacogenomic associations with chemotherapy-induced toxicities in pediatric oncology. While certain genetic variants show associations with specific toxicities, larger multinational/center studies are needed to strengthen the associations and improve clinical guidelines.
    Review • Journal
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    ERCC2 (Excision repair cross-complementation group 2) • GSTP1 (Glutathione S-transferase pi 1) • MTHFR (Methylenetetrahydrofolate Reductase) • ABCC2 (ATP Binding Cassette Subfamily C Member 2) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • ABCC3 (ATP Binding Cassette Subfamily C Member 3) • GSTM1 (Glutathione S-transferase mu 1) • HAS3 (Hyaluronan Synthase 3) • RARG (Retinoic Acid Receptor Gamma) • GSTT1 (Glutathione S-transferase theta 1) • SLC22A2 (Solute Carrier Family 22 Member 2) • SLC28A3 (Solute Carrier Family 28 Member 3) • CELF4 (CUGBP Elav-Like Family Member 4) • COMT (Catechol-O-Methyltransferase)
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    methotrexate
    10ms
    Network pharmacology and in silico approach to study the mechanism of quercetin against breast cancer. (PubMed, In Silico Pharmacol)
    It also reverses drug resistance and has antioxidant and anti-inflammatory properties. This study concludes that the therapeutic influence of quercetin plays a significant role in treating breast cancer and aids in the advancement of the clinical application of quercetin in future studies.
    Journal
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    AKT1 (V-akt murine thymoma viral oncogene homolog 1) • ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1)
    11ms
    Edaravone is a Therapeutic Candidate for Doxorubicin-Induced Cardiomyopathy by Activating the Nrf2 Pathway. (PubMed, Pharmacol Res Perspect)
    However, there is limited evidence that EDA is effective against DICM. The findings obtained herein bolster the evidence in DICM by demonstrating prolonged survival and continued preservation of cardiac function and proposing a possible mechanism.
    Journal
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    ABCB4 (ATP Binding Cassette Subfamily B Member 4)
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    doxorubicin hydrochloride • dexrazoxane
    11ms
    Liver GPBAR1 Associates With Immune Dysfunction in Primary Sclerosing Cholangitis and Its Activation Attenuates Cholestasis in Abcb4-/- Mice. (PubMed, Liver Int)
    Our study provides evidence for the therapeutic potential of selective GPBAR1 agonists in intestinal inflammation-associated cholestasis, warranting the evaluation of BAR501 in PSC patients.
    Preclinical • Journal
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    KRT19 (Keratin 19) • ABCB4 (ATP Binding Cassette Subfamily B Member 4)
    1year
    The association of ABC proteins with multidrug resistance in cancer. (PubMed, Biochim Biophys Acta Mol Cell Res)
    We further discussed that the most commonly used drugs in standard regimens for mainly breast cancer, lung cancer, and acute lymphoblastic leukemia could be subject to MDR mediated by ABC transporters. Collectively, these insights will aid in conducting new studies aimed at a deeper understanding of the clinical MDR mediated by ABC proteins and in designing more effective pharmacological treatments to enhance the objective response rate in cancer patients.
    Review • Journal
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    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • ABCC10 (ATP Binding Cassette Subfamily C Member 10) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • ABCF2 (ATP Binding Cassette Subfamily F Member 2) • ABCG1 (ATP Binding Cassette Subfamily G Member 1) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)