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BIOMARKER:

ABCB1 G2677T

i
Other names: ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1, ATP-binding cassette, sub-family B (MDR/TAP), member 1
Entrez ID:
Related biomarkers:
7ms
The current study provides preliminary evidence of a significant association between variant TT genotype and increased B-ALL risk. Also, results suggest that ABCB1 3435TT genotype increases imatinib resistance in CML and influence therapeutic outcome in B-ALL.
Clinical • Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
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ABCB1 C3435T • ABCB1 G2677T
|
imatinib
12ms
We showed that in childhood B-ALL, the intracellular VCR levels in lymphoblasts affected treatment outcomes. The intracellular VCR level was independent of leukaemia subtype but dependent on host ABCB1 G2677T genotype.
Clinical • Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
|
ABCB1 G1236T + ABCB1 G2677T • ABCB1 G2677T
|
vincristine
1year
Similarly, no significant association was observed in the stratification analyses by ethnicity and control source. In conclusion, this meta-analysis suggests that ABCB1 G2677T/A polymorphism is not associated with genetic susceptibility to breast cancer.
Retrospective data • Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
|
ABCB1 G1236T + ABCB1 G2677T • ABCB1 G2677T