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BIOMARKER:

ABCB1 C3435T

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Other names: ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1, ATP-binding cassette, sub-family B (MDR/TAP), member 1
Entrez ID:
Related biomarkers:
4ms
Involvement of the ABCB1 C3435T Variant but Not the MTHFR C677T or MTHFR A1298C Variant in High-Dose Methotrexate-Induced Toxicity in Pediatric Acute Lymphoblastic Leukemia Patients in China. (PubMed, Int J Gen Med)
This study showed that the ABCB1 C3435T homozygous allele genotype (TT) is associated with increased MTX-related toxicities (leukopenia, neutropenia and oral mucositis). These results may help to distinguish pediatric ALL patients with a relatively high risk of MTX-related toxicities before HD-MTX infusion and optimize MTX treatment.
Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • MTHFR (Methylenetetrahydrofolate Reductase)
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MTHFR C677T • ABCB1 C3435T
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methotrexate
7ms
Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia. (PubMed, Drug Metab Pers Ther)
Complementing the existing criteria for pediatric ALL risk groups with pharmacogenetic indicators will allow further individualization of therapy.
Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
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ABCB1 C3435T
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methotrexate
10ms
Predicting toxicity following cancer chemotherapy by detecting transporter gene ABCB1 (C1236T, G2677T/A, C3435CT) polymorphism in breast cancer patients receiving chemotherapy with anthracycline and taxane either sequentially or concomitantly (ESMO Asia 2023)
Conclusions The homozygous mutant TT genotypes (C1236T and C3435T) and heterozygous CT genotypes (C1236T) showed significant association to chemo-induced toxicity (hematological toxicity, nausea, vomiting, alopecia) in patients underwent anthracycline and taxane. Hence, these SNPs could serve as predictive markers to mitigate chemotherapy's adverse effects and optimize treatment to reduce the grade of toxicity and improves patients quality of life.
Clinical
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
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ABCB1 3435C>T • ABCB1 C1236T • ABCB1 C3435T • ABCB1 G2677T
1year
Predictive modeling of adverse drug reactions to tamoxifen therapy for breast cancer on base of pharmacogenomic testing. (PubMed, Drug Metab Pers Ther)
Models that include both genetic and non-genetic determinants of ADRs of TAM may further improve the prediction of individual response to tamoxifen.
Journal • Adverse drug reaction
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9) • CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5)
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ABCB1 C3435T
|
tamoxifen
over1year
The Interaction between Four Polymorphisms and Haplotype of ABCB1, the Risk of Non-Small Cell Lung Cancer, and the Disease Phenotype. (PubMed, J Oncol)
As the findings indicate, lung cancer and control groups demonstrate significantly different patterns of -129/1236/2677/3435 haplotype distribution; T-T-T-T haplotype contributes to NSCLC susceptibility, and this effect is probably mainly dependent on C3435T. So far, similar studies were published in other populations.
Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
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ABCB1 C1236T • ABCB1 C3435T • ABCB1 G2677T
over1year
Pharmacogenetic Study of Ibrutinib Toxicity in Chronic Lymphocytic Leukemia Patients (ASH 2022)
A slight trend can be observed in subjects with mutated genotype of ABCB1 C3435T, C1236T and G2677T/A polymorphisms.CONCLUSIONSCLL treatment has a high rate of ADR, the main risk being bleeding. So far, polymorphisms in enzymes and transporters involved in the ibrutinib pathway have not been shown to affect the incidence of ADR in CLL patients, probably due to the small sample size of our study.In addition to increasing the sample size, steady-state plasma concentrations of ibrutinib will be measured in order to correlate drug levels with polymorphisms in the genes analyzed and the incidence of ADR.
Clinical
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4) • CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5)
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ABCB1 C1236T • ABCB1 C3435T • ABCB1 G2677T
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Imbruvica (ibrutinib)
2years
No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients-A 10-Year Follow-Up Study in the Polish Population. (PubMed, Genes (Basel))
However, they may not be the critical ones when it comes to risk or recovery assessment. Consequently, they may not be treated as reliable prognostic or predictive markers in breast cancer patients' evaluation, which supports the previous findings and current knowledge.
Journal
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PGR (Progesterone receptor) • ABCB1 (ATP Binding Cassette Subfamily B Member 1)
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ABCB1 C3435T • ABCB1 G2677T
over2years
The Relation of Haplotype ATP-binding Cassette B1 and Glutathione S-transferase P1 A313G Genes with Hematological Toxicity in Indonesian Breast Cancer Patients Receiving Chemotherapy. (PubMed, Oman Med J)
Indonesia breast cancer patients who underwent three cycles of chemotherapy demonstrated susceptibility to hematological toxicity by developing side effects such as anemia and neutropenia. However, no relationship was found between hematological toxicity and ABCB1 and GSTP1 polymorphisms.
Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • GSTP1 (Glutathione S-transferase pi 1)
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ABCB1 C1236T • ABCB1 C3435T • ABCB1 G2677T
over2years
High expression levels and the C3435T SNP of the ABCB1 gene are associated with lower survival in adult patients with acute myeloblastic leukemia in Mexico City. (PubMed, BMC Med Genomics)
In conclusion, we have found that the overexpression of the ABCB1 gene, as well as the presence of the TT genotype of the C3435T SNP, contributes to a worse prognosis in AML.
Clinical • Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
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ABCB1 overexpression • ABCB1 C3435T
over3years
Clinical utility of ABCB1 and ABCG2 genotyping for assessing the clinical and pathological response to FAC therapy in Mexican breast cancer patients. (PubMed, Cancer Chemother Pharmacol)
The early clinical response and its association with SNPs in the ABCB1 transporter are preserved until the pathological response to neoadjuvant chemotherapy; therefore, it could be used as a predictor of chemoresistance in locally advanced breast cancer patients of the Mexican population.
Clinical • Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2)
|
ABCB1 C3435T
|
5-fluorouracil • doxorubicin hydrochloride
over3years
Impact of ABCB1 Gene (C3435T/A2677G) Polymorphic Sequence Variations on the Outcome of Patients with Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia in Kashmiri Population: A Case-Control Study. (PubMed, Indian J Hematol Blood Transfus)
The current study provides preliminary evidence of a significant association between variant TT genotype and increased B-ALL risk. Also, results suggest that ABCB1 3435TT genotype increases imatinib resistance in CML and influence therapeutic outcome in B-ALL.
Clinical • Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
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ABCB1 C3435T • ABCB1 G2677T
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imatinib
over3years
Pharmacogenetics of tamoxifen therapy in Asian populations: from genetic polymorphism to clinical outcomes. (PubMed, Eur J Clin Pharmacol)
This review revealed more systematic pharmacogenomics of genes involved in the metabolism and transport besides CYP2D6, are required to optimize the genotyping strategies and guide the personalized tamoxifen therapy in Asian populations.
Clinical • Clinical data • Review • Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
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HR positive • ABCB1 C3435T
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tamoxifen
over3years
Association of plasma docetaxel levels with ABCB1 gene polymorphisms and tumour response in locally advanced breast cancer patients of South India on neo-adjuvant chemotherapy. (PubMed, Breast Cancer)
The plasma levels of docetaxel were significantly influenced by the SNP C1236T of ABCB1 gene coding for the MDR1 transporter (P-glycoprotein). The plasma levels of docetaxel were also found to influence its therapeutic effect.
Clinical • Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
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ABCB1 C1236T • ABCB1 C3435T
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docetaxel
almost4years
ABCB1 variants C3435T and T129C are not associated with colorectal cancer risk. (PubMed, Afr Health Sci)
For SNP T129C, all subjects showed normal (TT) genotype. There was no significant association between ABCB1 3435C>T and 129T>C polymorphisms with CRC risk.
Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1)
|
ABCB1 C3435T
4years
Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by ERCC1 or ABCB1. (PubMed, Future Oncol)
Japanese patients had significantly less good response to 5-fluorouracil/cisplatin chemotherapy. The influence of the three SNPs on response varied between patients from Japan and Germany. Different expressions of ERCC1 and ABCB1 SNPs of Japanese patients compared with the German patients partially explain the different response.
Clinical • Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ERCC1 (Excision repair cross-complementation group 1)
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ABCB1 C3435T
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cisplatin • fluorouracil topical