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    BIOMARKER:

    ABCB1 C1236T

    i
    Other names: ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1, ATP-binding cassette, sub-family B (MDR/TAP), member 1
    Entrez ID:
    5243
    Related biomarkers:
    Expression
    Mutation
    1year
    Predicting toxicity following cancer chemotherapy by detecting transporter gene ABCB1 (C1236T, G2677T/A, C3435CT) polymorphism in breast cancer patients receiving chemotherapy with anthracycline and taxane either sequentially or concomitantly (ESMO Asia 2023)
    Conclusions The homozygous mutant TT genotypes (C1236T and C3435T) and heterozygous CT genotypes (C1236T) showed significant association to chemo-induced toxicity (hematological toxicity, nausea, vomiting, alopecia) in patients underwent anthracycline and taxane. Hence, these SNPs could serve as predictive markers to mitigate chemotherapy's adverse effects and optimize treatment to reduce the grade of toxicity and improves patients quality of life.
    Clinical
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    ABCB1 (ATP Binding Cassette Subfamily B Member 1)
    |
    ABCB1 3435C>T • ABCB1 C1236T • ABCB1 C3435T • ABCB1 G2677T
    almost2years
    The Interaction between Four Polymorphisms and Haplotype of ABCB1, the Risk of Non-Small Cell Lung Cancer, and the Disease Phenotype. (PubMed, J Oncol)
    As the findings indicate, lung cancer and control groups demonstrate significantly different patterns of -129/1236/2677/3435 haplotype distribution; T-T-T-T haplotype contributes to NSCLC susceptibility, and this effect is probably mainly dependent on C3435T. So far, similar studies were published in other populations.
    Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1)
    |
    ABCB1 C1236T • ABCB1 C3435T • ABCB1 G2677T
    almost2years
    Pharmacogenetic Study of Ibrutinib Toxicity in Chronic Lymphocytic Leukemia Patients (ASH 2022)
    A slight trend can be observed in subjects with mutated genotype of ABCB1 C3435T, C1236T and G2677T/A polymorphisms.CONCLUSIONSCLL treatment has a high rate of ADR, the main risk being bleeding. So far, polymorphisms in enzymes and transporters involved in the ibrutinib pathway have not been shown to affect the incidence of ADR in CLL patients, probably due to the small sample size of our study.In addition to increasing the sample size, steady-state plasma concentrations of ibrutinib will be measured in order to correlate drug levels with polymorphisms in the genes analyzed and the incidence of ADR.
    Clinical
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4) • CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5)
    |
    ABCB1 C1236T • ABCB1 C3435T • ABCB1 G2677T
    |
    Imbruvica (ibrutinib)
    over2years
    The Relation of Haplotype ATP-binding Cassette B1 and Glutathione S-transferase P1 A313G Genes with Hematological Toxicity in Indonesian Breast Cancer Patients Receiving Chemotherapy. (PubMed, Oman Med J)
    Indonesia breast cancer patients who underwent three cycles of chemotherapy demonstrated susceptibility to hematological toxicity by developing side effects such as anemia and neutropenia. However, no relationship was found between hematological toxicity and ABCB1 and GSTP1 polymorphisms.
    Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • GSTP1 (Glutathione S-transferase pi 1)
    |
    ABCB1 C1236T • ABCB1 C3435T • ABCB1 G2677T
    almost4years
    Plasma imatinib levels and ABCB1 polymorphism influences early molecular response and failure-free survival in newly diagnosed chronic phase CML patients. (PubMed, Sci Rep)
    Also, patients who achieved EMR at 3 months, 6 months and MMR at 12 months had better FFS when compared to those who did not. This study suggests the incorporation of these variables in to the imatinib dosing algorithm as predictive biomarkers of response to Imatinib therapy.
    Clinical • Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1)
    |
    ABCB1 C1236T
    |
    imatinib
    4years
    Association of plasma docetaxel levels with ABCB1 gene polymorphisms and tumour response in locally advanced breast cancer patients of South India on neo-adjuvant chemotherapy. (PubMed, Breast Cancer)
    The plasma levels of docetaxel were significantly influenced by the SNP C1236T of ABCB1 gene coding for the MDR1 transporter (P-glycoprotein). The plasma levels of docetaxel were also found to influence its therapeutic effect.
    Clinical • Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1)
    |
    ABCB1 C1236T • ABCB1 C3435T
    |
    docetaxel