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    GENE:

    ABCA13 (ATP Binding Cassette Subfamily A Member 13)

    i
    Other names: ABCA13, ATP Binding Cassette Subfamily A Member 13, ATP-Binding Cassette, Sub-Family A (ABC1), Member 13, ATP-Binding Cassette Sub-Family A Member 13, FLJ33876, FLJ33951, ATP Binding Cassette Transporter A13
    Associations

    News

    Trials
    6ms
    Burn Injury Triggers Distinct Transcriptomic Profiles in Adipose Tissue of Adult and Aged Mice. (PubMed, FASEB J)
    Notably, Ppara and Sfpi1 emerged as potential master regulators of co-expressed genes in burn AT of adult and aged mice, respectively. Our findings highlight age-specific differences in burn-induced AT responses and uncover potential molecular regulators that may inform targeted therapeutic strategies to mitigate the post-burn stress response.
    Preclinical • Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • SPI1 (Spi-1 Proto-Oncogene) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • PPARA (Peroxisome Proliferator Activated Receptor Alpha) • ABCA13 (ATP Binding Cassette Subfamily A Member 13)
    1year
    Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma. (PubMed, Pharmaceuticals (Basel))
    Our multivariate analysis further demonstrated three ABC transporters, ABCA13 (Hazard Ratio (HR) = 1.31, p = 0.017), ABCB9 (HR = 1.26, p = 0.03), and ABCB5 (HR = 0.77, p = 0.016), with the administration of alkylating agents (HR = 0.41, p < 0.001), were independent negative prognosis factors for patients with GBM. These findings reinforce the important role played by ABC transporters, particularly by ABCA13, ABCB9, and ABCB1, which could be potential targets that warrant further evaluations for alternate strategies to augment the effects of existing alkylating agents and xenobiotic drugs.
    Review • Journal
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    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CD4 (CD4 Molecule) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • ABCA13 (ATP Binding Cassette Subfamily A Member 13)
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    temozolomide
    over1year
    Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic significance. (PubMed, Hum Genomics)
    The present study identified several putative somatic and germline genetic events with prognostic potential for colorectal cancer that should undergo functional characterization.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • LRP1B (LDL Receptor Related Protein 1B) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • FAT4 (FAT Atypical Cadherin 4) • RYR1 (Ryanodine Receptor 1) • GLI3 (GLI Family Zinc Finger 3) • COL6A3 (Collagen Type VI Alpha 3 Chain) • NAV3 (Neuron Navigator 3 ) • RIF1 (Replication Timing Regulatory Factor 1) • TENM4 (Teneurin Transmembrane Protein 4) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • FLG (Filaggrin) • RYR3 (Ryanodine Receptor 3) • ABCA13 (ATP Binding Cassette Subfamily A Member 13) • TCHH (Trichohyalin)
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    5-fluorouracil
    over1year
    Bulk and single-cell RNA sequencing reveal the contribution of laminin γ2 -CD44 to the immune resistance in lymphocyte-infiltrated squamous lung cancer subtype. (PubMed, Heliyon)
    LAMC2 and CD44 are epithelial-mesenchymal transition-associated genes that modulate tumor proliferation, and multicolor immunofluorescence validated the negative relationship between the expression of LAMC2-CD44 and immune infiltration. Thus, we identified a lymphocyte-infiltrated subtype (CS3) in patients with LUSC that exhibited resistance to immune checkpoint blockade therapy, and the co-hyperexpression of LAMC2-CD44 contributed to immune resistance, which could potentially improve immunological efficacy by targeting this molecule pair in combination with immunotherapy.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • LAG3 (Lymphocyte Activating 3) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • CD44 (CD44 Molecule) • LAMC2 (Laminin subunit gamma 2) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • DUSP4 (Dual Specificity Phosphatase 4) • ABCA13 (ATP Binding Cassette Subfamily A Member 13)
    2years
    Analysis of Somatic Mutations in the TCGA-LIHC Whole Exome Sequence to Identify the Neoantigen for Immunotherapy in Hepatocellular Carcinoma. (PubMed, Curr Issues Mol Biol)
    These genes are recognized to be immune targets. In the future, immune checkpoint inhibitors may be developed to prolong patient survival times and prevent hepatocellular carcinoma (HCC) through immunotherapy.
    Journal • IO biomarker
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    TP53 (Tumor protein P53) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MUC16 (Mucin 16, Cell Surface Associated) • MUC4 (Mucin 4, Cell Surface Associated) • APOB (Apolipoprotein B) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • PCLO (Piccolo Presynaptic Cytomatrix Protein) • TNN (Tenascin N) • ABCA13 (ATP Binding Cassette Subfamily A Member 13)
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    TP53 mutation
    2years
    Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases. (PubMed, Cancer Cell Int)
    The results encourage further molecular profiling for personalized treatment of colorectal cancer liver metastases discerning metachronous from synchronous scenarios.
    Journal • Tumor mutational burden
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    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • HRD (Homologous Recombination Deficiency) • MUC16 (Mucin 16, Cell Surface Associated) • FAT4 (FAT Atypical Cadherin 4) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • PCLO (Piccolo Presynaptic Cytomatrix Protein) • ABCA13 (ATP Binding Cassette Subfamily A Member 13)
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    TP53 mutation • KRAS mutation • PIK3CA mutation