AAK1 (AP2 Associated Kinase 1)

Moreover, in vitro experiments using miR-155-5p mimics and inhibitors, combined with Aak1 overexpression and interference, confirmed that the miR-155-5p-Aak1-Numb/Notch2 axis prevented DEX-induced disruption of PRV inhibition by Cur. These findings provide a novel regulatory target for preventing stress-activated PRV and provide evidence for the potential use of Cur as a stress modulator in practical applications.