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    BIOMARKER:

    84-gene expression signature

    10ms
    G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver. (PubMed, J Biochem)
    Furthermore, Tm-dependent upregulation of Gpr84 was blocked by the small chemical compound AEBSF, an inhibitor of ER stress transducers, in vitro and in vivo. In conclusion, the current study marks the discovery that the ER stress agent Tm induces the expression of Gpr84.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha)
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    84-gene expression signature
    1year
    CD84 (SLAMF5) As a Potential Target for Immunomodulation in Cutaneous T-Cell Lymphoma (CTCL) (ASH 2023)
    Our preliminary data from this exploratory study indicate that CD84 may be a potential target to reduce immunosuppression in CTCL. Further studies are needed to explore the functions of CD84 as an immune receptor in CTCL TME and its therapeutic potential in CTCL.
    PD(L)-1 Biomarker • IO biomarker • Immunomodulating
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    CD8 (cluster of differentiation 8) • CD163 (CD163 Molecule) • CD4 (CD4 Molecule)
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    PD-L1 expression • PD-1 expression • 84-gene expression signature • CD163 expression • CD4 expression
    over1year
    Analysis of myosin genes in HNSCC and identify MYL1 as a specific poor prognostic biomarker, promotes tumor metastasis and correlates with tumor immune infiltration in HNSCC. (PubMed, BMC Cancer)
    Moreover, there is a positive correlation between MYL1 expression and Tcm CD8 cells, Tcm CD4 + cells, NK cells, Mast cells, NKT cells, Tfh cells and Treg cells in HNSCC. Overall, MYL1 facilitates tumor metastasis and correlates with tumor immune infiltration in HNSCC and these effects may be associated with the EGF/EGFR pathway.
    Journal
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    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • MYH7 (Myosin Heavy Chain 7)
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    CD8 expression • 84-gene expression signature
    almost3years
    More Related Gene Pathways to Vincristine-Induced Death Events in a Human T-Acute Lymphoblastic Leukemia Cell Line. (PubMed, Rep Biochem Mol Biol)
    Some proteins like HSP90AA1 and ESR1 had determining associations with other proteins. The results suggest VCR target genes in T-ALL cells may be beneficial biomarkers for ALL treatment and can be used to select appropriate synergistic drugs for VCR.
    Preclinical • Journal
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    ER (Estrogen receptor) • CTSS (Cathepsin S) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
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    84-gene expression signature
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    vincristine