76-gene signature

Moreover, in our BC patients’ cohort and cell lines, we found a downregulation of miR-138–5p expression along with tumor progression, suggesting a negative regulation of the PDGFb/PDGFRb by miR138–5p. Conclusions Our preliminary results reveal the role of PDGFb/PDGFRb in maintaining tumor cells fitness and highlight a molecular loop involving PDGFRb and miR-138–5p in BC, that might represent not only a useful biomarker for improved diagnosis and patients’ stratification, but also as a promising axis that can be therapeutically targeted in situ.

This study suggests that YAP1 activation has an important prognostic effect on bladder cancer progression and might be useful in the selection of immunotherapy.