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    DRUG:

    6-thio-2′-Deoxyguanosine (THIO)

    i
    Other names: THIO, 6-thio-dG
    Associations

    News

    Trials
    Company:
    MAIA Biotech
    Drug class:
    Telomerase inhibitor
    Related drugs:
    Associations

    News

    Trials
    12ms
    Activating an Adaptive Immune Response with a Telomerase-mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma. (PubMed, Mol Cancer Ther)
    Importantly, the extracellular HMGB1 (high-mobility group box 1) protein acts as a prototypical endogenous DAMP (Damage Associated Molecular Pattern) in eliciting adaptive immunity by THIO. These results provide a strong rationale for combining telomere-targeted therapy with immunotherapy.
    Journal
    |
    HMGB1 (High Mobility Group Box 1)
    |
    6-thio-2′-Deoxyguanosine (THIO)