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DRUG:

6-thio-2′-Deoxyguanosine (THIO)

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Other names: THIO, 6-thio-dG
Associations
Trials
Company:
MAIA Biotech
Drug class:
Telomerase inhibitor
Associations
Trials
over1year
Activating an Adaptive Immune Response with a Telomerase-mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma. (PubMed, Mol Cancer Ther)
Importantly, the extracellular HMGB1 (high-mobility group box 1) protein acts as a prototypical endogenous DAMP (Damage Associated Molecular Pattern) in eliciting adaptive immunity by THIO. These results provide a strong rationale for combining telomere-targeted therapy with immunotherapy.
Journal
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HMGB1 (High Mobility Group Box 1)
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6-thio-2′-Deoxyguanosine (THIO)