^
    1m
    Radical Concurrent Chemoradiotherapy With DDP/5-FU and PD-1 Antibody for Non-metastatic Rectal Squamous Cell Carcinoma (clinicaltrials.gov)
    P2, N=20, Recruiting, Sixth Affiliated Hospital, Sun Yat-sen University | Trial completion date: Feb 2027 --> Jun 2029 | Trial primary completion date: Apr 2026 --> Sep 2026
    Trial completion date • Trial primary completion date
    |
    5-fluorouracil
    1m
    Co-clinical CT radiomics pipeline to establish candidate imaging biomarkers for colorectal cancer. (PubMed, Eur J Radiol)
    Orthotopic KRAS-mutant xenograft models (LOVO-Luc2 (N = 52) and SW480-Luc2 (N = 52)) were treated with standard-of-care regimens (FOLFOX, bevacizumab, or combination) and longitudinally imaged by CT (N = 104 tumour scans, N = 156 liver scans collected over 4 timepoints)...The most predictive features, GLSZM Gray Level Non-Uniformity, GLRLM Run Length Non-Uniformity Normalized, and GLDM Small Dependence Emphasis, were significantly associated with metastatic burden and survival in a clinical CRC cohort (N = 41), indicating species conservation and translational relevance. Collectively, these data demonstrate that preclinical CT radiomics can identify quantitative imaging features associated with treatment sensitivity and early metastatic progression, supporting translational potential.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase)
    |
    KRAS mutation • RAS mutation
    |
    Avastin (bevacizumab) • 5-fluorouracil • leucovorin calcium
    1m
    CRITⅡ: SCRT + Chemo Targeted Immuno-neoadjuvant Therapy for High-risk pMMR/MSS RC (clinicaltrials.gov)
    P3, N=204, Recruiting, Sixth Affiliated Hospital, Sun Yat-sen University | Not yet recruiting --> Recruiting
    Enrollment open • IO biomarker • pMMR
    |
    BRAF (B-raf proto-oncogene)
    |
    Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • oxaliplatin • leucovorin calcium
    1m
    Isatin-based oxime ethers as anticancer agents against human colorectal carcinoma. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)
    Even though this molecule is two-fold less active than reference drug 5-fluorouracil (5-FU), the pharmacophore of the compound 10d would be considered for future derivatisation as a notable anticancer agent, due to its safety profile against normal cell line HEK...The compound 10d demonstrated the greatest affinity for both targets (- 8.8 and - 7.9 kcal/mol, respectively), whereas other compounds showed favourable binding energies. These findings suggest that compound 10d may serve as a promising lead for further biological evaluation.
    Journal
    |
    BTK (Bruton Tyrosine Kinase)
    |
    5-fluorouracil
    1m
    GALNT5 drives colorectal cancer progression and chemoresistance via PI3K/Akt/ABCC1 axis. (PubMed, J Cancer Res Clin Oncol)
    GALNT5 facilitates malignant progression in CRC by promoting O-GalNAc glycosylation of EGFR and thereby activating the PI3K/Akt pathway, and confers resistance to L-OHP and 5FU through upregulation of ABCC1. These findings suggest GALNT5 as a potential diagnostic biomarker and a promising therapeutic target for overcoming chemoresistance in CRC.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • ABCC1 (ATP Binding Cassette Subfamily C Member 1)
    |
    5-fluorouracil • oxaliplatin • leucovorin calcium
    1m
    Bevacizumab, Fluorouracil, Leucovorin Calcium, and Oxaliplatin Before Surgery in Treating Patients With Stage II-III Rectal Cancer (clinicaltrials.gov)
    P2, N=17, Terminated, University of Southern California | Active, not recruiting --> Terminated; Insufficient Accrual
    Trial termination
    |
    Avastin (bevacizumab) • 5-fluorouracil • oxaliplatin • leucovorin calcium
    1m
    A Study of GFH276 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors and Pancreatic Ductal Adenocarcinoma (PDAC) Harboring RAS Mutation (clinicaltrials.gov)
    P1/2, N=222, Not yet recruiting, Genfleet Therapeutics (Shanghai) Inc.
    New P1/2 trial
    |
    KRAS (KRAS proto-oncogene GTPase) • RAS (Rat Sarcoma Virus)
    |
    KRAS mutation • RAS mutation
    |
    Erbitux (cetuximab) • gemcitabine • 5-fluorouracil • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium
    1m
    Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer (clinicaltrials.gov)
    P1/2, N=186, Recruiting, Zhejiang Doer Biologics Co., Ltd. | Trial completion date: Jun 2026 --> Jun 2027 | Trial primary completion date: Apr 2026 --> Apr 2027
    Trial completion date • Trial primary completion date
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 negative • HER-2 expression
    |
    5-fluorouracil • capecitabine • oxaliplatin • irinotecan • leucovorin calcium
    1m
    A Randomized, Open-Label, Controlled, Multicenter Phase III Clinical Study of SHR-A1811 in Combination With Chemotherapy and Bevacizumab Versus Standard Therapy as First-Line Treatment for Advanced Colorectal Cancer (clinicaltrials.gov)
    P3, N=300, Not yet recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd.
    New P3 trial
    |
    Avastin (bevacizumab) • 5-fluorouracil • oxaliplatin • trastuzumab rezetecan (SHR-A1811) • leucovorin calcium • levoleucovorin calcium
    1m
    Hepatic Artery Infusion Chemotherapy Plus Donafenib in Patients With Hepatocellular Carcinoma After Surgery (clinicaltrials.gov)
    P2, N=30, Completed, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Not yet recruiting --> Completed | Trial completion date: Aug 2024 --> Sep 2025 | Trial primary completion date: Mar 2024 --> Sep 2025
    Trial completion • Trial completion date • Trial primary completion date
    |
    5-fluorouracil • oxaliplatin • leucovorin calcium • Zepsun (donafenib)
    1m
    ISMCC: Immunosurveillance for Metastatic Colorectal Cancer (clinicaltrials.gov)
    P2/3, N=187, Completed, MIPO Clinic | Active, not recruiting --> Completed | Phase classification: P1/2 --> P2/3
    Trial completion • Phase classification
    |
    5-fluorouracil • oxaliplatin • leucovorin calcium