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    DRUG CLASS:

    α1 adrenergic receptor antagonist

    Related drugs:
    18d
    PrePOURTS: Prevention of Post Operative Urinary Retention After Thoracic Surgery Trial (clinicaltrials.gov)
    P2, N=60, Recruiting, Lawson Health Research Institute | Trial completion date: May 2025 --> Feb 2026 | Initiation date: Jul 2024 --> Oct 2024 | Not yet recruiting --> Recruiting | Trial primary completion date: Dec 2024 --> Dec 2025
    Enrollment open • Trial completion date • Trial initiation date • Trial primary completion date • Surgery
    22d
    Prevention of Postoperative Urinary Retention with Treatment of Tamsulosin 5 Days Prior to Lower Limb Arthroplasty (clinicaltrials.gov)
    P4, N=170, Active, not recruiting, Kantonsspital Graubünden | Recruiting --> Active, not recruiting | Trial completion date: Jun 2024 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Oct 2024
    Enrollment closed • Trial completion date • Trial primary completion date
    1m
    OASIS: Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL) (clinicaltrials.gov)
    P2, N=180, Not yet recruiting, University of North Carolina, Chapel Hill
    New P2 trial
    1m
    Brain Blood Vessel Responses to Changes in Blood Flow (clinicaltrials.gov)
    P2, N=36, Not yet recruiting, University of Wisconsin, Madison
    New P2 trial
    1m
    Brain Blood Vessel Responses to Changes in Blood Flow (clinicaltrials.gov)
    P2, N=36, Not yet recruiting, University of Wisconsin, Madison
    New P2 trial
    2ms
    Efficacy and safety of Life Enhancer probiotic capsule in the treatment of chronic nonbacterial prostatitis (IIIB):A randomized, double-blind, placebo-controlled clinical study (ChiCTR2400087244)
    P3, N=200, Not yet recruiting, Shanghai Fourth People's Hospital Affiliated to Tongji University; Shanghai Fourth People's Hospital
    New P3 trial
    2ms
    A single centre pilot randomised controlled trial of enteral Guanfacine vs Quetiapine for agitated delirium in patients in the intensive care unit (ACTRN12624001075572)
    P2, N=36, Not yet recruiting, Austin Hospital
    New P2 trial
    2ms
    A pilot single-centre double-blind randomised controlled trial of the effect of centhaquine on stroke volume in the treatment of vasodilatory hypotension in adults admitted to the intensive care unit (ACTRN12624000384550)
    P2, N=18, Recruiting, Austin Health | Not yet recruiting --> Recruiting
    Enrollment open
    2ms
    A preliminary study of the addition of prazosin to radiotherapy in men with prostate cancer (ACTRN12621000784819)
    P1, N=30, Active, not recruiting, GenesisCare | Recruiting --> Active, not recruiting
    Enrollment closed
    3ms
    Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests (clinicaltrials.gov)
    P3, N=70, Recruiting, VA Office of Research and Development | Trial completion date: Sep 2024 --> Jan 2025 | Trial primary completion date: Jun 2024 --> Jan 2025
    Trial completion date • Trial primary completion date
    3ms
    ADAM: Efficacy and Safety of Longidaze in the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia (clinicaltrials.gov)
    P=N/A, N=229, Completed, NPO Petrovax
    New trial
    3ms
    Bioequivalence Study of Tamsulosin 0.4 mg Sustained Release Film-coated Tablets (clinicaltrials.gov)
    P1, N=28, Completed, Dexa Medica Group
    New P1 trial
    3ms
    Quetiapine Versus Trazadone in Women With Postpartum Depression (clinicaltrials.gov)
    P1, N=50, Not yet recruiting, Lawson Health Research Institute
    New P1 trial
    3ms
    VEGA-3: Evalyate Efficacy and Safety of POS to Improve Distance-corrected Near Visual in Participants With Presbyopia (clinicaltrials.gov)
    P3, N=545, Recruiting, Ocuphire Pharma, Inc.
    New P3 trial
    4ms
    Preoperative Tamsulosin to Prevent Postoperative Urinary Retention After Surgery For Pelvic Floor Disorders (clinicaltrials.gov)
    P1, N=100, Active, not recruiting, The Cleveland Clinic | Trial completion date: Jun 2024 --> Dec 2024 | Trial primary completion date: Feb 2024 --> Oct 2024
    Trial completion date • Trial primary completion date • Surgery
    4ms
    Hypoxia-Induced Pulmonary Injury-Adrenergic Blockade Attenuates Nitrosative Stress, and Proinflammatory Cytokines but Not Pulmonary Edema. (PubMed, J Cardiovasc Dev Dis)
    Eighty-six female rats were exposed for 72 h to normoxia or normobaric hypoxia and received infusions with NaCl, prazosin, propranolol, or prazosin-propranolol combination. The results suggest that hypoxia-induced sympathetic activation contributes to inflammation and nitrosative stress in the lungs but not to PE. We suggest that AB in hypoxia aggravates hypoxia-induced inotropic LV dysfunction and backlog into the pulmonary circulation, thus promoting PE.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha)
    4ms
    Comparative assessment of the absorption of a generic formulation of tamsulosin tablet against the innovator tamsulosin tablet conducted under fed condition in healthy male and female volunteers. (ACTRN12618001051235)
    P1, N=28, Completed, Zenith Technology Corp Ltd | Recruiting --> Completed
    Trial completion
    4ms
    Prazosin for Post-Concussive Headaches (clinicaltrials.gov)
    P4, N=89, Completed, Seattle Institute for Biomedical and Clinical Research | N=228 --> 89
    Enrollment change
    4ms
    Medications for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia (clinicaltrials.gov)
    P3, N=150, Recruiting, Tanta University
    New P3 trial
    5ms
    Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin (clinicaltrials.gov)
    P1/2, N=89, Completed, VA Office of Research and Development | N=166 --> 89
    Enrollment change
    5ms
    Effect of Preoperative Tamsulosin on Postoperative Urinary Retention (clinicaltrials.gov)
    P3, N=183, Completed, NorthShore University HealthSystem | Recruiting --> Completed
    Trial completion
    6ms
    PrePOURTS: Prevention of Post Operative Urinary Retention After Thoracic Surgery Trial (clinicaltrials.gov)
    P2, N=60, Not yet recruiting, Lawson Health Research Institute | Initiation date: Apr 2024 --> Jul 2024 | Trial primary completion date: Apr 2025 --> Dec 2024
    Trial initiation date • Trial primary completion date • Surgery
    6ms
    Use of Tamsulosin to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery (clinicaltrials.gov)
    P3, N=90, Terminated, Mayo Clinic | N=350 --> 90 | Recruiting --> Terminated; Slow recruitment and enrollment
    Enrollment change • Trial termination • Surgery
    6ms
    Effects of metformin and silodosin as supplementary treatments to abiraterone on human telomerase reverse transcriptase (hTERT) level in metastatic castration-resistant prostate cancer (mCRPC) cells: An in vitro study. (PubMed, Narra J)
    Our data indicated that the combination of metformin with AA and the combination of metformin, silodosin and AA decreased the hTERT levels when compared to control, AA, and silodosin with AA. The administration of metformin resulted in a reduction of hTERT levels in the PC3 cell line, but the impact of silodosin on hTERT levels was not statistically significant compared to AA group.
    Preclinical • Journal • Metastases
    |
    TERT (Telomerase Reverse Transcriptase)
    |
    abiraterone acetate • metformin
    6ms
    RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) (clinicaltrials.gov)
    P4, N=30, Not yet recruiting, University of Southern California | Trial completion date: Dec 2024 --> Dec 2026 | Trial primary completion date: Jul 2024 --> Jul 2026
    Trial completion date • Trial primary completion date
    7ms
    Post-operative Urinary Retention (POUR) Following Thoracic Surgery (clinicaltrials.gov)
    P1/2, N=127, Recruiting, Hackensack Meridian Health | Trial completion date: May 2025 --> Mar 2026 | Trial primary completion date: May 2025 --> Mar 2026
    Trial completion date • Trial primary completion date • Surgery
    7ms
    LYNX-2: Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects With Post-refractive Surgery Visual Disturbances (clinicaltrials.gov)
    P3, N=200, Recruiting, Ocuphire Pharma, Inc.
    New P3 trial • Surgery
    8ms
    Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI) (clinicaltrials.gov)
    P3, N=146, Not yet recruiting, Foundation for Advancing Veterans' Health Research
    New P3 trial
    8ms
    Prazosin for Post-Concussive Headaches (clinicaltrials.gov)
    P4, N=228, Completed, Seattle Institute for Biomedical and Clinical Research | Trial completion date: Dec 2024 --> Jun 2023 | Trial primary completion date: Dec 2023 --> May 2023 | Active, not recruiting --> Completed
    Trial completion • Trial completion date • Trial primary completion date
    8ms
    The cytotoxic effects of prazosin, chlorpromazine, and haloperidol on hepatocellular carcinoma and immortalized non-tumor liver cells. (PubMed, Med Oncol)
    Based on our findings, a mechanism of cell death was not able to be established due to lack of cleaved caspase-3 expression. Capable of bypassing many aspects of the lengthy, costly, and difficult cancer drug approval process, chlorpromazine and prazosin deserve further investigation for use in conjunction with traditional chemotherapeutics.
    Journal
    |
    CASP3 (Caspase 3)
    |
    chlorpromazine
    8ms
    Serum S100B Protein and White Matter Changes in Schizophrenia before and after Medication. (PubMed, Brain Res Bull)
    Our findings demonstrated abnormalities in S100B and WM microstructure in patients with schizophrenia. These abnormalities may be partly reversed by quetiapine treatment.
    Journal
    |
    S100B (S100 Calcium Binding Protein B)
    8ms
    FOLI: Function of Tamsulosin in Older Males Undergoing Surgery With Indwelling Catheter (clinicaltrials.gov)
    P3, N=212, Recruiting, Emory University | Not yet recruiting --> Recruiting
    Enrollment open • Surgery
    8ms
    A rare Ewing-like small round cell tumor in prostate: a case report and literature review. (PubMed, J Cancer Res Clin Oncol)
    Because of its non-elevated serum PSA level, prostate SRCT is often ignored as a possibility of malignant tumor and regarded as benign prostatic hyperplasia (BPH). The possibility of prostate SRCT need to be considered if dysuria symptoms could not alleviate significantly after a period of oral treatment.
    Review • Journal
    |
    ARID1A (AT-rich interaction domain 1A) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase) • BCL2L11 (BCL2 Like 11)
    |
    ARID1A mutation
    |
    finasteride
    9ms
    Roles of Breast Cancer Resistance Protein and Organic Anion Transporting Polypeptide 2B1 in Gastrointestinal Toxicity Induced by SN-38 under Inflammatory Conditions. (PubMed, Toxicol Lett)
    The expression alterations of breast cancer resistance protein (BCRP) and organic anion transporting polypeptide (OATP) 2B1 were determined at the mRNA and protein levels, and the subsequent functional alterations were evaluated via an accumulation study with the representative transporter substrates [prazosin and dibromofluorescein (DBF)] and SN-38...Treatment with rifampin or novobiocin supported the significant roles of BCRP and OATP2B1 in the transport and cytotoxic profile of SN-38. Collectively, these results suggest that BCRP and OATP2B1 are involved in the increased cytotoxicity of SN-38 under inflammatory conditions in vitro. Further comprehensive research is warranted to completely understand SN-38-induced gastrointestinal cytotoxicity and aid in the successful treatment of cancer with irinotecan.
    Journal
    |
    SLCO2B1 (Solute Carrier Organic Anion Transporter Family Member 2B1)
    |
    irinotecan • rifampicin
    9ms
    FOLI: Function of Tamsulosin in Older Males Undergoing Surgery With Indwelling Catheter (clinicaltrials.gov)
    P3, N=212, Not yet recruiting, Emory University
    New P3 trial • Surgery
    9ms
    PrePOURTS: Prevention of Post Operative Urinary Retention After Thoracic Surgery Trial (clinicaltrials.gov)
    P2, N=64, Not yet recruiting, Lawson Health Research Institute
    New P2 trial • Surgery
    10ms
    Silodosin in Retrograde Intrarenal Surgery (clinicaltrials.gov)
    P3, N=60, Completed, Ain Shams University | Enrolling by invitation --> Completed
    Trial completion
    |
    silodosin
    10ms
    Impact of Tamsulosin on Post-Operative Urinary Retention Following Pelvic Reconstructive Surgery (clinicaltrials.gov)
    P2, N=154, Recruiting, Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | Trial completion date: May 2025 --> Dec 2025 | Trial primary completion date: Aug 2024 --> Dec 2024
    Trial completion date • Trial primary completion date • Surgery
    11ms
    Post-operative Urinary Retention (POUR) Following Thoracic Surgery (clinicaltrials.gov)
    P1/2, N=127, Recruiting, Hackensack Meridian Health | Trial completion date: May 2024 --> May 2025 | Trial primary completion date: May 2024 --> May 2025
    Trial completion date • Trial primary completion date
    11ms
    RALLY: A Phase 3 Study To Evaluate The Efficacy And Safety Of TNX-102 SL In Patients With Fibromyalgia (clinicaltrials.gov)
    P3, N=514, Completed, Tonix Pharmaceuticals, Inc. | Terminated --> Completed
    Trial completion
    11ms
    A Study to Assess the Pharmacokinetic Profile of Prazosin and Cyproheptadine (clinicaltrials.gov)
    P1, N=8, Not yet recruiting, Kinnov Therapeutics
    Trial completion date • Trial initiation date • Trial primary completion date
    11ms
    Safety and Efficacy Study of TNX-102 SL in Participants With PTSD (clinicaltrials.gov)
    P2, N=0, Withdrawn, Tonix Pharmaceuticals, Inc. | N=220 --> 0 | Recruiting --> Withdrawn
    Enrollment change • Trial withdrawal