COMPANY:

PreludeDx

"Prelude Corporation...announced it has entered into a managed care provider agreement with MediNcrease Health Plans, a national provider network in the US, to make accessible the PreludeDx’s DCISionRT test to its clients and payers. Under the agreement, MediNcrease’s clients and payers, providers, and their patients throughout the U.S. will now have access to DCISionRT, the only risk assessment test for patients with ductal carcinoma in situ (DCIS) that predicts radiation therapy (RT) benefit."

"Prelude Corporation...announced it will be presenting data comparing risk stratification and radiation benefit (RT) for patients with ductal carcinoma in situ (DCIS) using DCISionRT™ with a clinicopathologic (CP) model similar to the Memorial Sloan Kettering Cancer Center (MSKCC) DCIS nomogram at the 40th Annual Miami Breast Cancer Conference (MBCC), being held on March 2 – 5, 2023 at the Fontainebleau Miami Beach....The study included 926 DCIS patients from four cohorts who were treated with breast conserving surgery (BCS) or BCS + radiation therapy (RT). The study compared MSKCC DCIS nomogram-like model with the DCISionRT 7-gene biosignature."

"Prelude Corporation...announced it has entered into a managed care provider agreement with Medical Cost Containment Professionals LLC (MCCP) to process out-of-network claims for PreludeDx’s DCISionRT test. Under the agreement, MCCP’s more than 150,000 providers nationwide and their patients throughout the U.S. will now have access to DCISionRT, the only risk assessment test for patients with ductal carcinoma in situ (DCIS) that predicts radiation therapy (RT) benefit."

P=NA | N=926 | "Prelude Corporation...announced study results demonstrating that DCISionRT provides patients with ductal carcinoma in situ (DCIS) superior recurrence risk stratification and radiation therapy (RT) benefit prediction compared to commonly used clinicopathologic (CP) features...This study....revealed in 926 women from four cohorts, that DCISionRT was a superior predictor of 10-year IBR rates and RT benefit compared to clinicopathologic criteria. DCISionRT identified that approximately half of CP-Low Risk patients were classified as elevated risk by the test and significantly benefited from RT with an absolute 17.7% reduction in 10-year ipsilateral breast recurrence. Whereas DCISionRT Low Risk patients, which included about one-third of CP High-Risk patients, had no significant RT benefit, representing a true low risk group."

"Prelude Corporation...announced today that data will be presented in four separate poster presentations at the 2022 San Antonio Breast Cancer Symposium (SABCS), to be held on December 6 – 10, 2022 at the Henry B. Gonzalez Convention Center in San Antonio, TX. Presentations will include a spotlight poster on DCISionRT and its identification of a low-risk group of DCIS patients with no benefit from adjuvant radiation, a poster addressing the role of DCISionRT in treatment implications for HER2(+) patients, and two separate presentations on the latest data in the Predict Registry studies from both the U.S. and Australia."

"GenesisCare...announced interim results from the AUSPREDICT registry. Data presented at the Australasian International Breast Congress demonstrates a significant (45%) change in radiation therapy treatment recommendations1 when using the DCISionRT test, optimising management to prevent over and under treatment of Australian women with Ductal Carcinoma In Situ (DCIS)."

"Prelude Corporation...announced study results demonstrating that DCISionRT provides patients with ductal carcinoma in situ (DCIS) superior risk and RT benefit prediction compared to common clinicopathologic features....This study...highlighted that clinicopathologic criteria were poor predictors of 10-year ipsilateral breast recurrence (IBR) rates and radiation therapy (RT) benefit in 926 women from four international cohorts."

"Prelude Corporation..announced today that its prospective data of 926 patients demonstrating the clinical utility of DCISionRT and its Residual Risk Subtype (RRt) was selected for a scientific session oral presentation at the 64th Annual American Society for Radiation Oncology (ASTRO) Meeting, to be held on October 23 – 26, 2022 at the Henry B. Gonzalez Convention Center in San Antonio, TX."

P=NA | N=926 | "Prelude Corporation...announced the publication of clinical study data in the International Journal of Radiation Oncology· Biology· Physics ('Red Journal'). The study demonstrated that the DCISionRT^® Residual Risk Subtype (RRt) identified ductal carcinoma in situ (DCIS) patients who had a much higher recurrence risk following breast conserving surgery (BCS) and radiation therapy (RT)....This study...evaluated 10-year recurrence risk in 926 women diagnosed with DCIS and treated with BCS with or without RT. Patients in the RRt group had a 42% risk of recurrence after BCS and a significantly elevated recurrence rate of 14.7% after BCS and RT."

"Prelude Corporation...announced compelling results in 926 women diagnosed with ductal carcinoma in situ (DCIS) identifying patients with low risk of recurrence independent of traditional clinicopathologic risk factors. Study results were presented today at the American Association for Cancer Research (AACR) Special Conference: Rethinking DCIS: An Opportunity for Prevention...The DCISionRT® test demonstrated that radiation did not significantly reduce the in-breast recurrence (IBR) rate in the low-risk group. However, the elevated/residual-risk group benefited significantly from radiation therapy (RT), with a 17.7% absolute 10-year IBR rate reduction."

"Prelude Corporation (PreludeDx)...announced...that it has signed an agreement with Galaxy Health Network to provide coverage for the company’s novel DCISionRT test for ductal carcinoma in situ (DCIS), also known as stage zero breast cancer. Under the agreement, Galaxy’s more than 3.5 million members and over 400,000 providers will now have access to DCISionRT."

"Prelude Corporation...announced today that it has signed an agreement with Three Rivers Provider Network, Inc. (TRPN)...Under the agreement, TRPN's more than 200 million members will now have access to DCISionRT."

"Prelude Corporation...announced compelling results in 926 women diagnosed with ductal carcinoma in situ (DCIS). The new information was presented in an oral abstract session at the American Society of Clinical Oncology (ASCO) Annual Meeting at McCormick Place, Chicago, IL...The results of the study demonstrated that after breast conserving surgery (BCS) patients in the DCISionRT elevated risk group had a significant risk reduction from endocrine therapy (ET), while those patients in the DS low risk group did not have a significant risk reduction from ET."

"Prelude Corporation...announced today that its study in 926 DCIS patients demonstrating the clinical utility of DCISionRT was selected for an oral presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting. The results evaluating the association of DCISionRT, a predictive DCIS Biosignature to assess the impact of Endocrine Therapy (ET) on 10-year ipsilateral breast recurrence (IBR) risk after breast conserving surgery alone or with radiation therapy (RT), will be presented on June 7, 2022 at McCormick Place, Chicago, IL."

"Prelude Corporation...announced compelling results in 926 women diagnosed with ductal carcinoma in situ (DCIS). The new information was presented in an oral presentation at the American Society of Breast Surgeons (ASBrS) 23rd Annual Meeting, held on April 6 - 10, 2022 at Wynn Las Vegas, NV...DCISionRT identified women with a low 5% 10-yr risk of recurrence with or without radiation therapy: overall and within either high-grade or young patients. Furthermore, the test predicted which patients had a superior benefit from radiation therapy (>70% relative risk reduction)."

"Prelude Corporation...announced today that its study in 926 patients demonstrating the clinical utility of DCISionRT and its Residual Risk Subtype (RRt) was selected for a scientific session oral presentation at the American Society of Breast Surgeons (ASBrS) 23rd Annual Meeting. The results assessing 10-year risk of ipsilateral breast recurrences in patients with grade 3 ductal carcinoma in situ (DCIS) disease and/or young age (<50 years) treated with breast conserving surgery (BCS) with or without radiation therapy (RT), will be presented on April 9, 2022 at Wynn Las Vegas, NV."

"Prelude Corporation...announced that it has closed a $20 million funding round led by Evidity Health Capital and joined by existing and new investors...Proceeds from this round will be used to advance the commercial market expansion of DCISionRT and the continued development of the company’s precision radiogenomics platform for early-stage breast cancer and other cancers."

"Prelude Corporation (PreludeDx), announced it will be presenting data comparing DCISionRT and its integrated Residual Risk subtype (RRt) with traditional clinicopathology features at the 39th Annual Miami Breast Cancer Conference (MBCC), being held on March 3 – 6, 2022 at the Fontainebleau Miami Beach...The poster is entitled, ‘Clinicopathological Risk Factors Poorly Stratified Baseline Risk and RT benefit Compared to DCISionRT in Patients with Ductal Carcinoma in Situ’ and will be available online for viewing during the duration of the conference and available in-person during the poster receptions on March 3rd and 4th."

"Prelude Corporation...announced the publication of SweDCIS randomized clinical trial data in the Special Issue Updates on Breast Cancer edition of Cancers. The randomized study demonstrates that the DCISionRT test predicts radiation benefit for reducing 10-year local invasive breast cancer risk...The study assessed 10-yr outcomes in 504 women treated with breast conserving surgery (BCS) and randomized into RT or no RT arms. Patients in the DCISionRT elevated risk group had a 9% significant reduction in invasive risk from radiation therapy. While women in the low risk group had a 1% non-significant difference after receiving radiation therapy. The results are highly consistent with three prior DCISionRT studies, further validating the predictive value of the assay."

"Prelude Corporation...announced today it will be presenting new data on its ongoing prospective PREDICT study of DCIS patients at the 2021 San Antonio Breast Cancer Symposium (SABCS), being held on December 7 – 10 at the Henry B. Gonzalez Convention Center in San Antonio, Texas. PreludeDx will present scientific data demonstrating a significant (40%) change in radiation therapy (RT) treatment recommendations when using the DCISionRT test."

"Prelude Corporation (PreludeDx)...announced today that the American Medical Association (AMA) has issued a new, dedicated Current Procedural Terminology (CPT®) Proprietary Laboratory Analyses (PLA) code for DCISionRT, the only test available to predict personalized recurrence risk and radiation therapy benefit for patients with ductal carcinoma in situ (DCIS). The new code 0295U, will become effective January 1, 2022 and is specific to the DCISionRT test."

"Prelude Corporation (PreludeDx)...announced today that it has entered into an agreement with MultiPlan, Inc., the nation’s leading provider of healthcare cost management solutions to participate in MultiPlan’s primary (PHCS) and complementary (MultiPlan) networks. Under terms of the agreement, more than 60 million members and nearly 1 million providers will have access to DCISionRT at discounted rates. DCISionRT a DCIS radio-genomic test, is the only test to predict personalized recurrence risk and radiation therapy benefit for patients with ductal carcinoma in situ (DCIS)."

"Prelude Corporation (PreludeDx)...presented data at the Society of Surgical Oncology (SSO) 2021 International Conference on Surgical Cancer Care. The study validated the clinical utility of the DCISionRT® biosignature to assess ipsilateral breast event (IBE) risk after breast conserving surgery (BCS) and the benefit of radiation therapy (RT). Women with ductal carcinoma in situ (DCIS) and Elevated Decision Scores (DS) had a significantly higher risk of IBE and a greater relative benefit from RT compared to women with lower DS."

"Prelude Corporation (PreludeDx™)…presented data at the Miami Breast Cancer Conference (MBCC) 2021 Annual Meeting examining the association of DCISionRT® test results with breast cancer mortality (BCM) in patients diagnosed with ductal carcinoma in situ (DCIS). Study results demonstrated patients with higher DCISionRT scores had an increased risk of BCM... The primary endpoint of the study was to identify the association of DCISionRT test results with breast cancer mortality. DCISionRT Decision Score (DS) results were available for 157 of the 414 women. Primary DCIS was treated with breast conserving surgery (BCS) alone, BCS plus radiotherapy or mastectomy in 34%, 29% and 37% of the cases, respectively. Results revealed patients with increasing continuous DS had increasing BCM (OR=10, p=0.004), and patients with high categorical DS (>6) were at greater risk of BCM (OR=19, p=0.007)."

"GenesisCare...and Prelude Corporation (PreludeDx™)...today announced a new strategic partnership aimed at increasing access to personalized breast cancer treatment and improved patient outcomes...The new partnership between GenesisCare and PreludeDx will make DCISionRT testing available in Australia, where the test is currently not offered, as well as increase patient access in the United States through GenesisCare’s network of integrated cancer treatment centers. Australian-headquartered GenesisCare is one of the largest networks of integrated oncology care in the world, with more than 440 treatment centers and clinics across the US, Australia, the UK, and Spain."

"Prelude Corporation (PreludeDx)…presented clinical outcomes data last week at the San Antonio Breast Cancer Symposium (SABCS) that further validates the DCISionRT test results of an independent study by Kaiser Permanente Northwest published earlier this year in Clinical Cancer Research…‘In this study we examined the utility of the DCISionRT test to identify patients who otherwise met traditional ‘good-risk’ criteria but remained at an elevated invasive risk after lumpectomy…’"

"Prelude Corporation (PreludeDx™)…announced today that it has signed an agreement to become a provider in the America's Choice Provider Network (ACPN). Under terms of the agreement, more than 30 million ACPN members from across the U.S. will have access and coverage for DCISionRT, the only DCIS Radio Genomic test that offers personalized recurrence risk and radiation therapy treatment benefit for patients with ductal carcinoma in situ (DCIS)."