COMPANY:

Gritstone bio

"Gritstone bio, Inc...presented an update on its T cell epitope discovery platform, EDGE, at the 2024 American Association for Cancer Research (AACR) Annual Meeting in San Diego, CA....Class I antigens – predicted using allele-specific and pan-specific models: Allele-specific model is an improved version of published 2018 EDGE model that predicts for 116 HLA alleles and achieves an Average Precision (AP) of 0.63 and Positive Predictive Value at 40% Recall (PPV40) of 0.79; Pan-specific model trains using the HLA allele sequence and is applicable to any Class I allele with known sequence, achieving an AP of 0.65 and PPV40 of 0.81; 2-fold better performance vs MHCFlurry 2.0 when ranking mutations from 80 cancer patients based on immunogenicity."

P2/3 | N=700 | NCT05141721 | Sponsor: Gritstone bio, Inc. | "Gritstone bio...announced positive preliminary data from the ongoing, signal seeking Phase 2 portion of the Phase 2/3 study evaluating GRANITE...in front-line metastatic microsatellite stable colorectal cancer (MSS-CRC)....Early progression-free survival (PFS) trends favor GRANITE recipients with hazard ratios of 0.82 in the overall population ([95% CI, 0.34-1.67]; 62% censored) and 0.52 (48% relative risk reduction of progression or death with GRANITE vs. control) in a high-risk group, where clinical data are more mature ([95% CI, 0.15-1.38]; 44% censored); >90% of high-risk patients have liver metastases....GRANITE was generally well-tolerated with manageable adverse events; no patients have discontinued GRANITE due to adverse events....Mature PFS data expected in the third quarter of 2024; overall survival data expected in 1H 2025."

"Gritstone bio, Inc...announced that the company has joined the ctMoniTR Project, a collaborative research initiative providing foundational evidence to inform future use of change in circulating tumor DNA (ctDNA) as an early indicator of long-term clinical benefit from therapeutics in cancer patients. The ctMoniTR Project is led by Friends of Cancer Research (Friends)."