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COMPANY:
Cofactor Genomics

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Other names: Cofactor Genomics | Cofactor Genomics, Inc. | Cofactor Genomics, Inc | Cofactor Genomics Inc. | Cofactor Genomics Inc
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Evidence

News

4ms
Cofactor Genomics’ immunotherapy predictive diagnostic, OncoPrism, completes validation and moves into clinical use in Head and Neck Cancer patients (BioSpace)
"Cofactor Genomics...announced successful validation of the OncoPrism immunotherapy predictive diagnostic assay, enabling physicians to use the test to help guide treatment decisions for patients with metastatic or recurrent squamous cell carcinoma of the head and neck (HNSCC)."
Clinical data
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OncoPrism™ Assay
11ms
Culmination Bio and Cofactor Genomics leverage largest biobank in the U.S. for PREDAPT precision medicine clinical trial (Businesswire)
"Culmination Bio...and Cofactor Genomics...announced a partnership to leverage samples and data from one of the largest biobanks in the country to fuel the development of Cofactor Genomic’s OncoPrism™ test in 11 cancers."
Licensing / partnership
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OncoPrism™ Assay
over1year
Cofactor Genomics Opens Enrollment for Non-small Cell Lung Cancer Study of OncoPrism Predictive Diagnostic Assay (Businesswire)
"Cofactor Genomics...today announced commencement of a study of its OncoPrism™ assay in non-small cell lung cancer (NSCLC), the second indication being studied in the company’s national PREDAPT study that will ultimately encompass 11 cancers....'We intend to grow our clinical and biomarker team quickly to expedite validation of our lung cancer assay so it will closely follow our head and neck cancer assay in 2023'."
Enrollment open
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OncoPrism™ Assay
over1year
Cofactor Genomics RNA-seq assay outperforms PD-L1 IHC to predict immunotherapy responders (Precision Medicine Online)
"Cofactor Genomics' OncoPrism platform, which combines immune cell quantification and T-cell subtyping, has outperformed PD-L1 testing as a method to identify cancer patients who will respond to immunotherapy...The San Francisco-based company's platform has shown in the PREDAPT trial that it was twice as accurate in identifying which patients would respond to immunotherapy compared to PD-L1 by immunohistochemistry. At a scientific meeting earlier this month, Cofactor reported data from the trial evaluating OncoPrism against standard PD-L1 IHC testing in patients with head and neck cancer, non-small cell lung cancer, and melanoma."
Clinical
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OncoPrism™ Assay
over1year
Cofactor Genomics Unveils New Data Showing Novel OncoPrism Diagnostic is Nearly Twice as Accurate as PD-L1 in Identifying Immunotherapy Responders (Cofactor Genomics Press Release)
"Data show that Cofactor's OncoPrism test using Predictive Immune Modeling was nearly twice as accurate as PD-L1 assays in determining patients that will benefit from immunotherapies such as Keytruda (pembrolizumab)....In clinical studies where OncoPrism was tuned to have the same sensitivity as PD-L1, Cofactor’s test reached 75% accuracy in predicting responders to immune checkpoint inhibitors, when compared to 42% accuracy for PD-L1. These interim results from nine healthcare systems show at similar sensitivity, OncoPrism has greater specificity and continues to be superior to single analyte approaches like PD-L1....The study results provide a strong framework and understanding for the other important cancers we will be studying in our broader PREDAPT work, including non-small cell lung cancer (NSCLC)."
Observational data
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OncoPrism™ Assay
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Keytruda (pembrolizumab)