COMPANY:

Caris Life Sci

''Caris Life Sciences®...published a study in JAMA Network Open, titled “An AI Approach to Differentiating Lung Squamous Cell Carcinoma From Metastases of Other Origins.” This study builds on the body of evidence showing the superiority of Caris’ proprietary and world-leading GPSai® algorithm over traditional diagnostic procedures in correctly diagnosing cancer types...The GPSai algorithm is included as part of MI Cancer Seek® and MI Tumor Seek® at no additional cost.''

''Caris Life Sciences®...today announced the launch of a novel, proprietary Caris AI Insights™ signature for pancreatic cancer included in the Caris Molecular Tumor Board Report. The Caris Molecular Tumor Board Report is an innovative tumor profiling report that provides an additional tumor biology resource and is available upon request with no additional tissue sampling required when ordering MI Cancer Seek®.''

''Caris Life Sciences®...today announced a new breast cancer signature included in the Caris Molecular Tumor Board Report. The Caris Molecular Tumor Board Report is an innovative research-use-only (RUO) tumor profiling report that provides an additional tumor biology resource and is available upon request when ordering MI Cancer Seek®.''

''Caris Life Sciences...today announced an interim readout of Achieve 1, the Company’s study supporting the upcoming launch of Caris Detect™, its multi-cancer early detection (MCED) test. This interim readout of Achieve 1 represents a major milestone in Caris’ goal to detect cancer earlier, when it is most treatable, through Whole Genome Sequencing, advanced AI and molecular insights.''

"Caris Life Sciences®...has published a study in Oncotarget validating the analytical and clinical performance of MI Cancer Seek®. This FDA-approved assay is used as a companion diagnostic (CDx) to identify cancer patients who may benefit from targeted therapies. It includes one pan-cancer and five tumor-specific indications for numerous FDA-approved therapies. MI Cancer Seek is the first and only test to combine whole exome sequencing (WES) and whole transcriptome sequencing (WTS) with FDA-approved CDx indications for solid tumor profiling in both adult and pediatric patients, marking a significant advancement in precision oncology."

"Caris Life Sciences®...has published a new study in Communications Medicine, a Nature portfolio journal, demonstrating that Caris’ AI-based image analysis model has the potential to more accurately predict cancer biomarkers and patient survival than the conventional companion diagnostic (CDx) methods. By analyzing hematoxylin and eosin (H&E) images, the study demonstrated that Caris’ AI model can improve the assessment of critical cancer biomarkers and impact patient survival outcomes in breast and colorectal cancers."

"Caris Life Sciences®...recently published a study on the development and validation of Caris’ latest version of Caris GPSai™ in AACR’s Cancer Research Communications Journal. Caris GPSai is a clinically validated deep learning multi-layer AI that leverages comprehensive whole exome and whole transcriptome sequencing (WES/WTS) to significantly improve diagnostic accuracy for cancers of unknown primary (CUP) and identify patients who have potentially misdiagnosed tumors."

"The CheckMate 8HW trial reported longer progression-free survival with Ipilimumab/Nivolumab (Ipi/Nivo) compared to Nivo monotherapy, but it remains unclear if all dMMR CRC patients should be offered ipi/nivo. Here, we investigated the survival benefit of Ipi/Nivo compared to Pembrolizumab (pembro) according to MutS vs. MutL co-loss...Assessment of mutS vs. mutL status provides a novel stratification that can further refine treatment algorithms for selection of specific ICI regimens in this patient population. Legal entity responsible for the study The authors."

"Caris Life Sciences®...announced a landmark study published in Scientific Reports, a Nature journal, demonstrating the accuracy and clinical utility of the Caris Assure® blood-based biopsy assay across the cancer continuum."

"Caris Life Sciences(Caris), a leading next-generation AI TechBio company and precision medicine pioneer, performs MET Immunohistochemistry (IHC) testing as standard of care for all non-squamous non-small cell lung cancer (NSQ NSCLC) patients and is poised for future drug approvals....Comprehensive Molecular Profiling: Caris utilizes a multi-platform approach, including immunohistochemistry (IHC) and next-generation sequencing (NGS), to provide a detailed molecular profile of NSQ NSCLC tumors. Identification of Actionable Targets: The MET IHC testing helps identify overexpression of the MET protein, which is associated with poor prognosis and can be targeted by specific therapies."

"Caris Life Sciences®...today announced a strategic collaboration with MiBA, an innovative healthcare technology company to provide physician education and insights to accelerate research, identify and personalize treatment plans. This partnership aims to help improve patient care and advance precision medicine by supporting oncologists’ experience with Next Generation Sequencing (NGS) testing and supporting clinical research through operational optimization, BioPharma clinical trials and real-world data project identification."

"Caris Life Sciences...today announced the publication of 'Real-world evidence provides clinical insights into tissue-agnostic therapeutic approvals' in Nature Communications...the study provides a comprehensive evaluation of real-world outcomes for patients eligible for these powerful 'pan-cancer' therapies, such as pembrolizumab and larotrectinib...Key findings include: More than 20 percent of patients are candidates for a tissue-agnostic drug. Approximately five percent of patients who lacked any tumor-specific indication were found to carry a tissue-agnostic indication and became eligible for tissue-agnostic drug treatment. Tissue-agnostic therapy uptake was poor for rare indications, illustrating the need for enhanced clinical education. Current tissue-agnostic indications could potentially be expanded, as evidenced by clinical benefits in tumor types and drugs of the same class that were not investigated in the original clinical trials."