^
    CANCER:

    Thyroid Gland Carcinoma





    Show legend
    Group by Gene:
    Include preclinical:

    cabozantinib capsule
    vandetanib
    		0
    Multi-tyrosine kinase inhibitor
    cabozantinib tablet
    AMG 706
    ponatinib
    regorafenib
    selpercatinib
    pralsetinib
    RET inhibitor
    SY-5007
    BOS-172738
    		1
    RET inhibitor
    EP0031
    LDD-2633
    TAS0953 / HM06
    TY-1091
    HG-6-63-01
    XMD15-44
    2
    DNA synthesis inhibitor
    cisplatin
    dacarbazine
    3
    TrkB receptor inhibitor, TrkC kinase inhibitor, TrkA receptor inhibitor
    larotrectinib
    4
    RANK ligand inhibitor
    denosumab
    5
    Topoisomerase II inhibitor
    doxorubicin hydrochloride
    6
    Tubulin polymerization promoter, Bcl2 inhibitor
    paclitaxel
    carboplatin + paclitaxel
    selumetinib
    		7
    MEK inhibitor
    trametinib
    CI-1040
    8
    BRAF inhibitor, BRAF V600E inhibitor
    vemurafenib
    FORE-8394
    PD1 inhibitor
    		9
    PD1 inhibitor
    pembrolizumab
    tislelizumab
    10
    MEK inhibitor, BRAF inhibitor
    BRAF inhibitor + MEK inhibitor
    trametinib + dabrafenib
    11
    mTOR inhibitor, Multi-tyrosine kinase inhibitor
    everolimus + vandetanib
    12
    ICAM-1-targeted CAR-T immunotherapy
    AIC100
    13
    ALK inhibitor
    crizotinib
    alectinib
    BRAF inhibitor
    		14
    BRAF inhibitor
    dabrafenib
    PLX4720
    15
    mTOR inhibitor
    everolimus
    sirolimus
    16
    MEK inhibitor, mTOR inhibitor, BRAF inhibitor
    trametinib + dabrafenib + everolimus
    17
    PD1 inhibitor, Multi-tyrosine kinase inhibitor
    anlotinib + sintilimab
    18
    TrkB receptor inhibitor, TrkC kinase inhibitor, ROS1 inhibitor, TrkA receptor antagonist
    AB-106
    19
    VEGFR-2 inhibitor, PD1 inhibitor
    camrelizumab + rivoceranib
    20
    VEGFR-2 inhibitor
    rivoceranib
    21
    PD-L1 inhibitor, LAG-3 inhibitor
    FS118
    22
    EGFR inhibitor
    erlotinib
    23
    PD1 inhibitor, BRAF inhibitor, BRAF V600E inhibitor
    nivolumab + vemurafenib
    24
    IL-6 inhibitor
    siltuximab
    25
    PD1 inhibitor, MEK inhibitor, BRAF inhibitor
    pembrolizumab + trametinib + dabrafenib
    trametinib + dabrafenib + sintilimab
    26
    pan-RAF inhibitor, Multi-tyrosine kinase inhibitor
    sorafenib
    27
    FGFR inhibitor, VEGFR inhibitor, RET inhibitor, c-KIT inhibitor, PDGFR α antagonist
    lenvatinib
    28
    Topoisomerase II inhibitor, Microtubule stabilizer, Tubulin polymerization promoter
    docetaxel + doxorubicin hydrochloride
    29
    PD-L1 inhibitor, MEK1 inhibitor
    atezolizumab + cobimetinib
    30
    Immunotherapy
    Immunotherapy
    31
    Chemotherapy
    CaT
    32
    FGFR inhibitor, VEGFR inhibitor, RET inhibitor, PD1 inhibitor, c-KIT inhibitor, PDGFR α antagonist
    pembrolizumab + lenvatinib
    33
    TrkB receptor inhibitor, TrkC kinase inhibitor, ROS1 inhibitor, TrkA receptor inhibitor, ALK inhibitor, JAK2 inhibitor, TNK2 inhibitor
    entrectinib
    34
    BRAF inhibitor, MEK1 inhibitor, BRAF V600E inhibitor
    vemurafenib + cobimetinib
    35
    pan-RAF inhibitor, EGFR inhibitor
    BGB-283
    36
    RET inhibitor, Src kinase inhibitor
    TPX-0046
    37
    PD-L1 inhibitor, BRAF inhibitor, BRAF V600E inhibitor
    atezolizumab + vemurafenib
    38
    VEGFR inhibitor, PDGFR inhibitor, c-KIT inhibitor
    sunitinib
    39
    pan-RAF inhibitor, CXCL12 inhibitor, Farnesyl transferase inhibitor, Multi-tyrosine kinase inhibitor
    sorafenib + tipifarnib
    40
    MEK inhibitor, BRAF inhibitor, MEK2 inhibitor, MEK1 inhibitor, BRAF V600E inhibitor
    vemurafenib + HL-085
    41
    BRAF inhibitor, BRAF V600E inhibitor, Cytochrome P450 inhibitor
    FORE-8394 + cobicistat
    42
    mTOR inhibitor, mTORC2 inhibitor
    Torin1
    43
    P21-activated kinase inhibitor
    FRAX597
    44
    Bcr-abl tyrosine kinase inhibitor, ERK inhibitor, Src kinase inhibitor, c-KIT inhibitor, PDGFR β antagonist, EphA2 receptor antagonist
    dasatinib + SCH772984
    dasatinib + CI-1040
    		45
    Bcr-abl tyrosine kinase inhibitor, MEK inhibitor, Src kinase inhibitor, c-KIT inhibitor, PDGFR β antagonist, EphA2 receptor antagonist
    dasatinib + selumetinib
    trametinib + dasatinib
    46
    Bcr-abl tyrosine kinase inhibitor, Src kinase inhibitor, c-KIT inhibitor, PDGFR β antagonist, EphA2 receptor antagonist
    dasatinib
    47
    VEGFR-2 inhibitor, PI3K inhibitor, mTOR inhibitor, BRAF inhibitor
    RTB101 + RAF265
    48
    Aurora kinase inhibitor, MEK inhibitor, SRC-family kinase (SFK) inhibitor
    CI-1040 + SU6656
    49
    MEK inhibitor, Src kinase inhibitor
    CI-1040 + PP2
    50
    mTOR inhibitor, AKT inhibitor
    temsirolimus + MK-2206
    51
    AKT inhibitor
    MK-2206
    52
    HER2 inhibitor, BRAF inhibitor, EGFR inhibitor
    lapatinib + PLX4720
    53
    ERK inhibitor, BRAF inhibitor
    dabrafenib + SCH772984
    54
    JAK1 inhibitor, JAK2 inhibitor
    AZD1480
    AZ 628
    		55
    pan-RAF inhibitor
    RG6185
    LY3009120
    56
    EphA2 receptor antagonist
    ALW-II-41-27
    57
    Aurora kinase A inhibitor
    MLN8237
    58
    VEGFR inhibitor, BRAF inhibitor
    dabrafenib + axitinib
    PLX4720 + axitinib
    59
    RET inhibitor, mTORC1 inhibitor, FLT3 inhibitor, mTORC2 inhibitor
    CB-228 + AST-487
    60
    RET inhibitor, FLT3 inhibitor
    AST-487
    61
    ERK2 inhibitor, MEK inhibitor
    BAY86-9766
    62
    ERK2 inhibitor, MEK inhibitor, mTOR inhibitor
    temsirolimus + BAY86-9766
    63
    HER2 inhibitor, EGFR inhibitor, Multi-tyrosine kinase inhibitor
    AEE788
    64
    BRAF inhibitor, Multi-tyrosine kinase inhibitor
    ponatinib + PLX4720
    65
    Tubulin polymerization promoter
    carboplatin
    66
    MEK inhibitor, BRAF inhibitor, WEE1 inhibitor
    trametinib + dabrafenib + AZD1775
    67
    WEE1 inhibitor
    AZD1775
    68
    MEK inhibitor, MDM2 inhibitor
    selumetinib + KRT-232
    69
    Jumonji H3K27 demethylase inhibitor
    GSKJ4
    70
    Src kinase inhibitor
    PP2
    71
    VEGFR-2 inhibitor, BRAF inhibitor
    RAF265
    72
    Aurora kinase inhibitor, SRC-family kinase (SFK) inhibitor
    SU6656
    73
    pan-RAF inhibitor, RIPK3 inhibitor, RIPK1 inhibitor
    TAK‐632
    No biomarker
    RET M918T
    RET mutation
    RET C634R
    RET C618R
    RET C634F
    RET L629P
    RET D631_R635delinsG
    RET V804M
    RET fusion
    RET V804L
    RET exon 11 deletion
    RET V804M + M918T
    RET Y900_S904delinsP
    RET C634*
    RET C620R
    RET V804*
    RET positive
    RET V637R
    RET C634W
    RET rearrangement
    RET C634Y
    RET V804M + RET M918T + RET G810 + RET Y806
    BRAF V600E
    BRAF V600
    BRAF mutation
    BRAF T1799A
    NRAS mutation
    NRAS Q61R
    NRAS Q61K
    NTRK1 fusion
    NTRK1 overexpression
    NTRK1 positive
    KRAS mutation
    BRAF V600E + PD-L1 expression
    BRAF V600E + PD-L1 expression
    PD-L1 expression + BRAF negative
    KRAS G12R
    ALK1 overexpression
    ATM S978fs*12
    PIK3CA H1047R
    EGFR overexpression
    PIK3CA Q546K
    PD-L1 overexpression
    NTRK2 fusion
    NTRK3 fusion
    NTRK2 positive
    NTRK3 positive
    EGFR L858R
    PD-L1 expression
    ATM L804fs*4
    ALK1 rearrangement
    EGFR mutation
    PIK3CA E545K
    PIK3CA mutation
    PD-L1 expression + NRAS Q61R + BRAF D594N
    HRAS Q61R + TP53 P278S + PD-L1 overexpression
    CCDC6-ALK fusion
    BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L
    PD-L1 negative + TMB-L
    PAX8 positive
    NCOA4-RET fusion
    TPM3-NTRK1 fusion
    NF2 mutation
    GLI1 overexpression
    GLI2 overexpression
    NF1 mutation
    TMB-H
    GLI3 overexpression
    RET M918T + ATM L804fs*4 + ATM S978fs*12
    PDGFRB overexpression
    CCDC6-RET fusion
    MSI-H/dMMR
    TERT positive + PD-L1 expression
    CCDC6‐RET fusion + TERT promotor mutation
    RAS mutation
    RET-PTC1 rearrangement
    NRAS G13D + BRAF V600E
    NRAS Q61K + BRAF V600E
    KRAS G12V + BRAF V600E
    MTOR F2108L
    TSC2 Q1178X
    BRAF V600E + TERT mutation
    miR-340 expression
    miR-361 expression
    miR-363 expression
    miR-3651 expression
    miR-3917 expression
    miR-409 expression
    miR-4467 expression
    miR-4473 expression
    miR-449c expression
    miR-425 expression
    miR-4664 expression
    miR-4745 expression
    miR-504 expression
    miR-543 expression
    miR-584 expression
    miR-660 expression
    miR-664a expression
    miR-7 expression
    miR-760 expression
    miR-92a-1 expression
    miR-424 expression
    miR-100 expression
    miR-1293 expression
    miR-96 expression
    miR-99a expression
    miR-320a expression
    miR-490 expression
    HRAS G13R
    miR-769 expression
    HRAS G12V
    HRAS G13R
    miR-335 expression
    miR-331 expression
    miR-328 expression
    miR-3200 expression
    miR-3187 expression
    miR-30d expression
    miR-30b expression
    miR-27b expression
    miR-27a expression
    miR-24-2 expression
    miR-23b expression
    miR-23a expression
    miR-2277 expression
    miR-21 expression
    miR-192 expression
    miR-185 expression
    miR-184 expression
    miR-155 expression
    miR-146a expression
    miR-132 expression
    miR-1301 expression
    miR-1291 expression
    miR-1287 expression
    miR-128 expression
    PTEN R130del
    FGFR1 overexpression
    PTEN mutation
    PTCH1 rearrangement
    MYC overexpression
    TERT mutation + BRAF V600E
    HMGB1 underexpression
    CASP12 overexpression
    CYCS overexpression
    CASP8 overexpression
    CASP3 overexpression
    WEE1 underexpression