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Association details:
| Biomarker: | YAP1 positive |
|---|---|
| Cancer: | Cholangiocarcinoma |
| Drug: | Truseltiq (infigratinib) (FGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma
Excerpt:
Yes-associated protein (YAP) nuclear localization and up-regulation of canonical target genes was observed in CCA cell lines and a patient-derived xenograft (PDX)….A significant reduction in tumor size was noted in the BGJ398-treated mice compared with vehicle-treated mice in the YAP positive PDX1 but not the YAP-negative PDX2 animals...
DOI:
https://dx.doi.org/10.1074%2Fjbc.M115.698472
