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Association details:
Evidence:
Evidence Level:
Sensitive: C4 – Case Studies
Title:

US phase 1 first-in-human study of taletrectinib (DS-6051b/AB-106), a ROS1/TRK inhibitor, in patients with advanced solid tumors

Published date:
06/26/2020
Excerpt:
There were 4 patients who achieved confirmed partial responses (two CD74-ROS1+ NSCLC, one TPM3-NTRK1+ thyroid cancer, and one small bowel NET patient)....Only one patient (metastatic TPM3-NTRK1+ papillary thyroid cancer) with an NTRK fusion enrolled to the study, who achieved a DOR of 33.4 months at the time of last tumor assessment...
DOI:
10.1158/1078-0432.CCR-20-1630
Trial ID: