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Association details:
| Biomarker: | TPM3-NTRK1 fusion |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | golvatinib (E7050) (c-KIT inhibitor, c-MET inhibitor, VEGFR-2 inhibitor, Angiogenesis inhibitor, EPH receptor inhibitor, RON inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs
Published date:
11/10/2017
Excerpt:
Here, we present an in vivo imaging model for brain tumors using human cancer cell lines, including the EGFR-L858R/T790M-positive H1975 lung adenocarcinoma cells...KM12SM colorectal cancer cells containing the TPM3-NTRK1 gene fusion. In addition, KM12SM and KM12C cells displayed similar sensitivities to other MET inhibitors, such as golvatinib and GW441756.
DOI:
10.1002/cam4.1255
