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Association details:
Biomarker:TP53 wild-type
Cancer:Solid Tumor
Drug:MK-8242 (MDM2 inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Title:

MK-8242 Is Active in Patients with p53 Wild-Type Advanced Solid Tumors

Excerpt:
In a phase I dose-ranging study, Wagner and colleagues evaluated MK-8242 in 47 patients with TP53–wild-type advanced solid tumors, 27 of whom had liposarcoma. The recommended phase II dose was determined to be 400 mg. The ORR was 6.4%, with an ORR of 11.1% in patients with liposarcoma. Three patients achieved partial responses and 31 showed stable disease. The median progression-free survival was 3.4 months overall and 7.8 months in patients with liposarcoma. Taken together, the results of this phase I trial indicate that MK-8242 has an acceptable safety profile at the determined recommended dose, and may have antitumor activity in patients with p53–wild-type tumors, particularly those with liposarcoma. Taken together, the results of this phase I trial indicate that MK-8242 has an acceptable safety profile at the determined recommended dose, and may have antitumor activity in patients with p53–wild-type tumors, particularly those with liposarcoma.
DOI:
10.1158/2159-8290.CD-RW2017-047