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Association details:
| Biomarker: | TP53 mutation |
|---|---|
| Cancer: | HER2 Positive Breast Cancer |
| Drug: | AZD1390 (ATM kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ATM inhibitor AZD1390 sensitizes breast cancer brain metastasis to radiation therapy
Published date:
03/10/2021
Excerpt:
Three PDX models (2 Her2+ and one triple negative), all of which harbor TP53 mutations and other DDR alterations, were implanted into the flank or brain of immunocompromised mice. Pre-treatment with AZD1390 followed by a fractionated regime of radiation therapy (2Gy/ day for 5 days) significantly inhibited growth of flank
