^
Association details:
| Biomarker: | TP53 mutation |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | AZD1390 (ATM kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
2598 / 11 - AZD1390 radio-sensitizes p53-mutant GBM via disrupting homology directed DNA repair
Published date:
03/09/2022
Excerpt:
IR/AZD1390 treatment resulted in significant survival extension...However, when stratified by TP53 status, combination therapy was significantly more effective...in TP53-mutant PDXs, where all 5 models benefited....
