All 21 heavily treated patients with r/r DLBCL who received zanubrutinib-combined regimens as bridging therapy are included...The zanubrutinib combined regimens are zanubrutinib with IMIDs, chemotherapy and/or rituximab...Of the 21 evaluable patients, median age of patients is 57 year old and median treatment line is 3. 19 patients (90%) are non-GCB subtype and 18 patients(86%) are IPI score >3. 14 patients(67%) are double expression and 7 patients (33%) have TP53 mutation. Objective response rate(ORR) is 81%; of whom, 10 patients(48%) got complete remission(CR) and 7 patients(33%) got partial remission(PR). With a median follow-up of 25 months, the median PFS was 12.8 months...Zanubrutinib-combined regimens are effective and safe as bridging therapy in CD19 CAR-T therapy.