^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

ONC-212 (I-39), a Novel Inhibitor of the UPR, Is Cytotoxic and Cytostatic Against CLL Cells Under in Vitro Conditions That Mimic the Tumor Microenvironment

Published date:
11/01/2018
Excerpt:
OSU-CLL cells were modified using the CRISPr-Cas9 technology to be TP53 deficient (OSU-TP53ko)...OSU-CLL and OSU-TP53ko cells were also sensitive to ONC-212…