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Association details:
| Biomarker: | TP53 deletion |
|---|---|
| Cancer: | Chronic Lymphocytic Leukemia |
| Drug: | ONC212 (ClpP agonist, GPR132 agonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ONC-212 (I-39), a Novel Inhibitor of the UPR, Is Cytotoxic and Cytostatic Against CLL Cells Under in Vitro Conditions That Mimic the Tumor Microenvironment
Published date:
11/01/2018
Excerpt:
OSU-CLL cells were modified using the CRISPr-Cas9 technology to be TP53 deficient (OSU-TP53ko)...OSU-CLL and OSU-TP53ko cells were also sensitive to ONC-212…
