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Association details:
Evidence:
Evidence Level:
Resistant: D – Preclinical
Title:

Downregulation of death receptor 4 is tightly associated with positive response of EGFR mutant lung cancer to EGFR-targeted therapy and improved prognosis

Published date:
02/15/2021
Excerpt:
Increased levels of DR4 were detected in cell lines with acquired osimertinib resistance and in NSCLC tissues relapsed from EGFR-targeted therapy...gefitinib, erlotinib or icotinib.
DOI:
10.7150/thno.54824