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Association details:
| Biomarker: | TNFA elevation |
|---|---|
| Cancer: | Small Cell Lung Cancer |
| Drug: | Yervoy (ipilimumab) (CTLA4 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Serum cytokine levels as predictive biomarkers of benefit from ipilimumab in small cell lung cancer
Published date:
03/27/2019
Excerpt:
...evaluated the potential predictive role of cytokines in patients treated with ipilimumab….Patients with a serum TNFα concentration above cut-off had a median OS of 7.8 m while those with lower levels had 18.5 m (p = 0.004)...while high IL-6 and TNF-alpha predicted resistance...Blood-based biomarkers are convenient for patients, and our results support prospective validation of cytokines as predictive biomarkers for ipilimumab in SCLC.
DOI:
10.1080/2162402X.2019.1593810
