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    Association details:
    Biomarker:TNFA elevation
    Cancer:Breast Cancer
    Regimen: (5-fluorouracil + cyclophosphamide + doxorubicin hydrochloride)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    Ann Med Surg (Lond)
    Title:

    Tumour necrosis factor-alpha levels as predictor factor on clinical response of anthracycline-based neoadjuvant chemotherapy in locally advance breast cancer patients: experimental research

    Published date:
    04/03/2023
    Excerpt:
    Participants received anthracycline-based neoadjuvant chemotherapy (cyclophosphamide of 500 mg/m2, doxorubicin of 50 mg/m2 and fluorouracil/5FU of 500 mg/m2) for 3 cycles….Based on cutoff 1, most participants with high TNF-α levels also had a negative response of 83.3% and those with low TNF-α levels also had a positive response of 75% (P<0.001)....TNF-α levels predict clinical response for anthracycline-based neoadjuvant chemotherapy in locally advanced breast cancer patients.
    DOI:
    10.1097/MS9.0000000000000424