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    Association details:
    Biomarker:STRN-ALK rearrangement
    Cancer:Mesothelioma
    Drug:cisplatin (DNA synthesis inhibitor) +
    gemcitabine (DNA synthesis inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    Transl Oncol
    Title:

    STRN-ALK rearranged pediatric malignant peritoneal mesothelioma – Functional testing of 527 cancer drugs in patient-derived cancer cells

    Published date:
    01/30/2021
    Excerpt:
    FM-MPeM-01 PDCs were analyzed for the expression of STRN-ALK...most cytotoxic drugs were not very effective, including gemcitabine and cisplatin...
    DOI:
    https://doi.org/10.1016/j.tranon.2021.101027