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Association details:
| Biomarker: | STK33 underexpression |
|---|---|
| Cancer: | Chordoma |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Afatinib Is a New Therapeutic Approach in Chordoma with a Unique Ability to Target EGFR and Brachyury
Excerpt:
Afatinib displayed potent antitumor efficacy in U-CH1, SF8894, CF322, and CF365 chordoma tumor models in vivo In the panel analyzed...low AXL and STK33 expression correlated with higher sensitivity to afatinib…
DOI:
10.1158/1535-7163.MCT-17-0324
