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Association details:
| Biomarker: | SSBP2-CSF1R fusion |
|---|---|
| Cancer: | B Acute Lymphoblastic Leukemia |
| Drug: | dasatinib (c-KIT inhibitor, Bcr-abl tyrosine kinase inhibitor, Src kinase inhibitor, EphA2 receptor antagonist, PDGFR β antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia
Excerpt:
Cells expressing ABL2, CSF1R, and JAK2 fusions have enhanced STAT5 activation, which is inhibited by dasatinib in RCSD1–ABL2 and SSBP2–CSF1R and by ruxolitinib in PAX5–JAK2.
DOI:
https://dx.doi.org/10.1056%2FNEJMoa1403088
