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Association details:
| Biomarker: | SPINK1 overexpression |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | Xtandi (enzalutamide) (Androgen receptor inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
miR-5089-5p suppresses castration-resistant prostate cancer resistance to enzalutamide and metastasis via miR-5089-5p/SPINK1/ MAPK/MMP9 signaling
Published date:
06/21/2020
Excerpt:
SPINK1 overexpression was significantly associated with decreased overall survival (Figure 1G). Taken together, SPINK1 acts as an oncogene in PCa, and promotes Enz resistance and metastasis.
DOI:
10.18632/aging.103485