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Association details:
| Biomarker: | SORL1 deletion |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | Nerlynx (neratinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance
Published date:
01/08/2021
Excerpt:
...loss of SorLA compromised heregulin-induced cell proliferation and sensitized metastatic anti-HER2 therapy-resistant breast cancer cells to neratinib in cancer spheroids in vitro and in vivo in a zebrafish brain xenograft model.
DOI:
doi.org/10.1038/s41388-020-01604-5