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DRUG:

VRx-510

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Company:

Viracta Therap

Drug class:

PDK1 inhibitor

Related drugs:

‹

dichloroacetate topical (1)

dichloroacetate topical (1)

›

KRAS G12C	Pancreatic Cancer	KRAS G12C	Pancreatic Cancer	sotorasib + VRx-510 Sensitive: D – Preclinical sotorasib + VRx-510 Sensitive : D	sotorasib + VRx-510 Sensitive: D – Preclinical sotorasib + VRx-510 Sensitive : D
KRAS G12C	Non Small Cell Lung Cancer	KRAS G12C	Non Small Cell Lung Cancer	sotorasib + VRx-510 Sensitive: D – Preclinical sotorasib + VRx-510 Sensitive : D	sotorasib + VRx-510 Sensitive: D – Preclinical sotorasib + VRx-510 Sensitive : D
TP53 mutation	Diffuse Large B Cell Lymphoma	TP53 mutation	Diffuse Large B Cell Lymphoma	venetoclax + VRx-510 Sensitive: D – Preclinical venetoclax + VRx-510 Sensitive : D	venetoclax + VRx-510 Sensitive: D – Preclinical venetoclax + VRx-510 Sensitive : D
CDKN2A deletion	Estrogen Receptor Positive Breast Cancer	CDKN2A deletion	Estrogen Receptor Positive Breast Cancer	palbociclib + VRx-510 Sensitive: D – Preclinical palbociclib + VRx-510 Sensitive : D	palbociclib + VRx-510 Sensitive: D – Preclinical palbociclib + VRx-510 Sensitive : D
CDKN2A deletion	Estrogen Receptor Positive Breast Cancer	CDKN2A deletion	Estrogen Receptor Positive Breast Cancer	ribociclib + VRx-510 Sensitive: D – Preclinical ribociclib + VRx-510 Sensitive : D	ribociclib + VRx-510 Sensitive: D – Preclinical ribociclib + VRx-510 Sensitive : D
PIK3CA mutation	Estrogen Receptor Positive Breast Cancer	PIK3CA mutation	Estrogen Receptor Positive Breast Cancer	ribociclib + VRx-510 Sensitive: D – Preclinical ribociclib + VRx-510 Sensitive : D	ribociclib + VRx-510 Sensitive: D – Preclinical ribociclib + VRx-510 Sensitive : D
PIK3CA mutation	Estrogen Receptor Positive Breast Cancer	PIK3CA mutation	Estrogen Receptor Positive Breast Cancer	palbociclib + VRx-510 Sensitive: D – Preclinical palbociclib + VRx-510 Sensitive : D	palbociclib + VRx-510 Sensitive: D – Preclinical palbociclib + VRx-510 Sensitive : D
PAK4 deletion	Estrogen Receptor Positive Breast Cancer	PAK4 deletion	Estrogen Receptor Positive Breast Cancer	ribociclib + VRx-510 Sensitive: D – Preclinical ribociclib + VRx-510 Sensitive : D	ribociclib + VRx-510 Sensitive: D – Preclinical ribociclib + VRx-510 Sensitive : D
PAK4 deletion	Estrogen Receptor Positive Breast Cancer	PAK4 deletion	Estrogen Receptor Positive Breast Cancer	palbociclib + VRx-510 Sensitive: D – Preclinical palbociclib + VRx-510 Sensitive : D	palbociclib + VRx-510 Sensitive: D – Preclinical palbociclib + VRx-510 Sensitive : D