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Association details:
| Biomarker: | SMAD4 deletion |
|---|---|
| Cancer: | Head and Neck Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer
Published date:
02/10/2022
Excerpt:
In addition, SMAD4-deficient HPV-positive cells have increased sensitivity to cisplatin treatment....Moreover, we found that SMAD4 silencing in HPV-positive HNC cell lines increases sensitivity to cisplatin treatment, suggesting that HPV-positive HNC with low SMAD4 expression may be preferentially susceptible to similar treatments.
DOI:
10.1186/s13046-022-02258-9
